PMID: 22555137May 5, 2012Paper

HPV testing in primary cervical screening: a systematic review and meta-analysis

Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'obstétrique Et Gynécologie Du Canada : JOGC
Joan MurphyLawrence Paszat

Abstract

Previous findings from cross-sectional studies have shown human papillomavirus (HPV) testing to be more sensitive than cytology testing for primary cervical screening. This systematic review aims to assess whether the increase in baseline detection with HPV testing corresponds to lower rates in subsequent screening rounds. We searched Medline, EMBASE, and the Cochrane Library for randomized controlled trials (published from 2005 to 2010) comparing HPV-based and cytology-based cervical screening. Primary outcomes of interest were relative rates of higher grade cervical intraepithelial neoplasia and invasive cervical cancer. Secondary outcomes included test performance characteristics and colposcopy referral rates. Results were pooled where possible using a random effects model. Seven randomized trials were identified. Across studies, HPV testing was more accurate than conventional cytology and detected significantly more CIN3+ in the first screening round (Mantel-Haenszel [M-H] risk ratio 1.67; 95% CI 1.27 to 2.19) and significantly less in the second screening round (M-H RR 0.49; 95% CI 0.37 to 0.66). There were no differences in pooled rates of CIN2+ (M-H RR 1.19; 95% CI 0.94 to 1.50) and CIN3+ (M-H RR 1.09; 95% CI 0.84 to 1.4...Continue Reading

Citations

Jun 12, 2013·International Journal of Cancer. Journal International Du Cancer·Gina S OgilvieEduardo L Franco
Apr 4, 2014·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Robin M TurnerLes Irwig
Dec 23, 2014·Journal of Applied Research in Intellectual Disabilities : JARID·H Ouellette-KuntzY Lunsky
Nov 13, 2015·American Journal of Public Health·Putu DuffKate Shannon
Sep 23, 2018·Journal of Global Oncology·Erin MosesSheona M Mitchell-Foster
Aug 13, 2015·The Journal of Rural Health : Official Journal of the American Rural Health Association and the National Rural Health Care Association·C Sarai Racey, Dionne C Gesink
Oct 11, 2020·Acta Obstetricia Et Gynecologica Scandinavica·Olga VeijalainenJohanna Mäenpää
Jan 11, 2021·Journal of the American Society of Cytopathology : JASC·Laila NomaniGüliz A Barkan
Jun 26, 2014·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Lise M A De StrooperDaniëlle A M Heideman
Sep 15, 2019·Gynécologie, Obstétrique, Fertilité & Sénologie·C GonthierG Canlorbe

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