H.pylori Infection Alleviates Acute and Chronic Colitis with the Expansion of Regulatory B Cells in Mice

Inflammation
Xia LiJingtong Wang

Abstract

Epidemiological studies showed that there was an inverse relationship between Helicobacter pylori (H. pylori) infection and the incidence of inflammatory bowel diseases (IBD). Our previous research indicated that the regulatory immune responses induced by H. pylori infection were not limited to gastric mucosa, and the balance of intestinal mucosal immunity was influenced. In this study, mice were infected with H. pylori SS1, and then colitis was induced by 3% dextran sulphate sodium (DSS), to investigate the role of the regulatory B cells in the effects of H. pylori infection on acute and chronic colitis. In acute and chronic colitis groups, DAI and colonic histological scores reduced significantly and colon length shorted less, the proinflammatory cytokines mRNA expression downregulated in colonic mucosa, and the percentages of CD19+IL-10+Breg cells were higher in the H. pylori/DSS co-treated groups compared with the DSS-treated groups. Our study suggests that H. pylori infection can alleviate the acute and chronic colitis induced by DSS, and CD19+IL-10+Breg cells may play a critical role in the alleviation of acute and chronic colitis following H. pylori infection.

References

Dec 9, 1998·Clinical and Experimental Immunology·L A DielemanE P Van Rees
Dec 25, 2004·Infection and Immunity·Anna LundgrenB Samuel Lundin
Sep 24, 2005·Helicobacter·Ernst J Kuipers, Pierre Michetti
May 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Shigenori NagaiShigeo Koyasu
Jun 15, 2007·Journal of Epidemiology and Community Health·Olf HerbarthThomas Richter
Nov 26, 2009·Journal of Clinical Immunology·Nicola Eastaff-LeungSimon Barry
Feb 2, 2011·The American Journal of Pathology·Koichi YanabaShinichi Sato
Jan 10, 2012·Alimentary Pharmacology & Therapeutics·A Sonnenberg, R M Genta
Apr 25, 2012·Applied Microbiology and Biotechnology·Lin-Li ChangChih-Hsing Hung
Oct 15, 2013·Journal of Pediatric Gastroenterology and Nutrition·Joo Hyun GilHye Youn Sung
Mar 4, 2014·World Journal of Gastroenterology : WJG·Aline Cristina Targa CadamuroAna Elizabete Silva
Mar 13, 2014·Biochemical and Biophysical Research Communications·Yanbing DingWeijuan Gong
Aug 30, 2014·Helicobacter·Mario M D'Elios, Steven J Czinn
Oct 31, 2014·Inflammatory Bowel Diseases·Md Mesbah Uddin AnsaryYoshikazu Kinoshita
Dec 3, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·José L ReyesDerek M McKay
Apr 23, 2015·Immunity·Elizabeth C Rosser, Claudia Mauri
Apr 29, 2015·World Journal of Gastroenterology : WJG·Xiao-Wei WuFang-Yu Wang
Jun 15, 2015·Journal of Autoimmunity·Fang-Ting LuZhe-Xiong Lian

❮ Previous
Next ❯

Citations

Jul 23, 2020·Gastroenterology Research and Practice·Jesús K Yamamoto-FurushoJanette Furuzawa-Carballeda
Feb 6, 2021·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Mohammad-Javad SanaeiNader Bagheri

❮ Previous
Next ❯

Methods Mentioned

BETA
Reverse-Transcription Polymerase Chain Reaction
PCR
flow cytometry

Software Mentioned

Statistical Package for Social Science
SPSS
GraphPad Prism
FlowJo

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.