HRCT and histopathological evaluation of fibrosis and tissue destruction in IPF associated with pulmonary emphysema

Respiratory Medicine
Paola RoglianiAugusto Orlandi

Abstract

Idiopathic pulmonary fibrosis has been associated with emphysema in cigarette smokers as a new clinical entity: combined pulmonary fibrosis and emphysema (CPFE). In order to compare histomorphometrical, roentgenological and immunohistochemical aspects of usual interstitial pneumonia (UIP) with and without associated pulmonary emphysema, 17 patients with biopsy-proven UIP were evaluated. Morphometrical evaluation of lung parenchyma destruction was used to divide patients in two subgroups: emphysema/UIP (n=9) and UIP alone (n=8); four patients with biopsy-proven emphysema without fibrosis were also evaluated. At HRTC scan, emphysematous lesions were prevalent in the upper fields of both emphysema/UIP and emphysema groups and the distribution of fibrotic lesions was similar in emphysema/UIP compared to UIP alone. The semiquantitative histopathological fibrotic score was also similar in emphysema/UIP and UIP alone. In addition, the expression of tumor necrosis factor (TNF)-alpha, matrix metalloproteinase (MMP)-2, MMP-9, MMP-7 and membrane type 1-metalloproteinase (MT1-MMP) by fibroblasts of myofibroblastic foci was similar in emphysema/UIP and UIP alone patients. In contrast, fibroblasts in areas of parenchymal destruction of emphy...Continue Reading

References

Jul 23, 1982·Science·D E Niewoehner, J R Hoidal
Jan 1, 1993·Respiration; International Review of Thoracic Diseases·N HiwatariT Takishima
Apr 1, 1993·The American Review of Respiratory Disease·W V CardosoW M Thurlbeck
May 1, 1997·American Journal of Respiratory and Critical Care Medicine·A U WellsR M du Bois
Mar 6, 1998·Thorax·M J DohertyP M Calverley
Feb 15, 2001·Annals of Internal Medicine·M SelmanUNKNOWN American College of Chest Physicians
Dec 24, 2002·American Journal of Respiratory Cell and Molecular Biology·Jeffrey J Atkinson, Robert M Senior
Dec 2, 2004·The European Respiratory Journal·A M VignolaP Chanez
May 28, 2005·The American Journal of Pathology·Augusto OrlandiLuigi Giusto Spagnoli
Oct 6, 2005·The European Respiratory Journal·V CottinUNKNOWN Groupe d'Etude et de Recherche sur les Maladies Orphelines Pulmonaires (GERM O P)
Mar 21, 2006·Clinics in Chest Medicine·Paul W Noble
Apr 26, 2006·Proceedings of the American Thoracic Society·Stephen I Rennard
Jun 2, 2006·Proceedings of the American Thoracic Society·Annie Pardo, Moisés Selman
Aug 24, 2006·Current Opinion in Pulmonary Medicine·J Shirine Allam, Andrew H Limper

❮ Previous
Next ❯

Citations

Nov 1, 2009·Expert Opinion on Medical Diagnostics·Philippe A GrenierPierre-Yves Brillet
Jan 5, 2012·Chest·Matthew D Jankowich, Sharon I S Rounds
Jul 9, 2009·Chest·Vincent Cottin, Jean-François Cordier
Sep 26, 2012·Pulmonary Pharmacology & Therapeutics·Maria G MateraAugusto Orlandi
Aug 3, 2010·Archivos de bronconeumología·Karina Portillo CarrozJosep Morera Prat
Jun 19, 2010·Medicina clínica·Karina Portillo Carroz, Juan Roldán Sánchez
Sep 22, 2010·Histopathology·Joanne L WrightAndrew Churg
Apr 21, 2012·Respirology : Official Journal of the Asian Pacific Society of Respirology·Sadatomo TasakaTomoko Betsuyaku
Jun 17, 2015·The Clinical Respiratory Journal·Pawan GuptaSunil K Chhabra
Aug 6, 2016·Respiratory Medicine·Andriana I PapaioannouSpyridon A Papiris
Mar 14, 2017·Journal of Managed Care & Specialty Pharmacy·Kelly FleetwoodMark Fisher
Jul 12, 2012·Current Opinion in Pulmonary Medicine·Vincent Cottin, Jean-François Cordier
Jul 17, 2014·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·Olívia Meira DiasCarlos Roberto Ribeiro Carvalho
Jun 29, 2017·American Journal of Respiratory and Critical Care Medicine·Vincent CottinAthol U Wells
Feb 1, 2013·Expert Review of Respiratory Medicine·Spyros A PapirisDemosthenes Bouros
Dec 17, 2017·Japanese Journal of Radiology·Tae IwasawaTakashi Ogura
Mar 22, 2019·ERJ Open Research·Foteini MalliZoe Daniil
Mar 22, 2021·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Steven D NathanAthol U Wells

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.