Abstract
Heat shock proteins (HSPs) are released in response to stress situations, such as heat, inflammation, and infection. They are also involved in the tumor cell proliferation and prevention of apoptosis. Heat shock protein 105 (Hsp105/110) is a high-molecular-weight protein, which has been reported in many cancer types but few studies have been carried out on oral squamous cell carcinoma (OSCC). In the current study, we have focused on HSP105 expression on OSCC and evaluated their correlation with tumor clinicopathological parameters and patients' survival. A retrospective study included 70 patients with OSCC of which 50 patients (71.4%) were male and 20 (28.6%) were female. The patient's information, including age, location, TNM stage, histological grade, regional metastasis, recurrence, and survival, were collected. Immunohistochemical staining for HSP105 was performed. The healthy oral mucosa (n = 10) was used as a control. The staining intensity and percentage of stained cells were semi-quantitatively evaluated, and HSP105 expression was correlated with tumor clinicopathological features and patient survival. Statistical analysis for HSP105 showed that there was no significant correlation with tumor clinicopathological feature...Continue Reading
References
May 12, 2000·European Journal of Biochemistry·J KumagaiT Tanaka
May 20, 2003·Journal of Gastroenterology and Hepatology·Tae Sook HwangYoung-Mee Park
Jun 29, 2004·The Journal of Pathology·Reinhard UllmannHelmut Hans Popper
Jul 11, 2006·Journal of Pediatric Hematology/oncology·Péter HauserMiklós Garami
Jul 11, 2006·Cancer Science·Seiji HosakaYasuharu Nishimura
Jul 22, 2006·Experimental Cell Research·Nobuyuki YamagishiTakumi Hatayama
Aug 17, 2006·The British Journal of Dermatology·F C MuchemwaT Kageshita
Jul 30, 2008·Cell Stress & Chaperones·Harm H KampingaLawrence E Hightower
Apr 11, 2009·Oncology Reports·O SlabyR Vyzula
May 30, 2009·Journal of Cutaneous Pathology·Hye-Sang ParkMoon K Cho
Jul 22, 2009·Developmental Cell·Bryan T MacDonaldXi He
Jan 5, 2011·Medicina oral, patología oral y cirugía bucal·Nooshin MohtashamKazem Anvari
Jul 1, 2009·Molecular Medicine Reports·Tomofumi OdaMeinoshin Okumura
Oct 26, 2013·Cancer Letters·Hongjun GaoXiaohang Zhao
Nov 28, 2013·Scientifica·Stuart K Calderwood
Mar 22, 2014·Molecular and Clinical Oncology·Taketo KawaiYukio Homma
Feb 24, 2015·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Deepika Bablani PopliVatchala Rani
Mar 5, 2016·Oncotarget·Akiharu KimuraHiroyuki Kuwano
Mar 15, 2016·Frontiers in Immunology·Daming ZuoXiang-Yang Wang
Oct 4, 2017·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Hyeon Jeong OhGyeong Hoon Kang
Citations
Feb 7, 2021·Medicine·Wei LuQingyun Duan
Jun 25, 2021·Clinical, Cosmetic and Investigational Dermatology·Meng JiaSheng Fang
Oct 8, 2021·PloS One·Ke-Jun ChenSheng Fang