HSP27: A new target for treating idiopathic pulmonary fibrosis?

Revue des maladies respiratoires
L PommerolleF Goirand

Abstract

Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal disease without therapeutic options. The development of new therapeutic strategies for the disease is needed. IPF is characterized by myofibroblast accumulation and collagen overproduction. Transforming growth factor-β1 (TGF-β1) is a key cytokine activating these pathological processes. Heat shock proteins (HSPs) are crucial regulators and promote TGF-β1 activity. Among them, HSP27 is overexpressed in animal models and in the lung of patients with IPF. HSP27 activates pro-fibrotic mechanisms and therefore may represents a potential target. Strategies aiming to inhibit HSP27 might pave the way towards new treatment options for patients with IPF.

References

Dec 2, 2008·The European Respiratory Journal·F DrakopanagiotakisD Bouros
Nov 17, 2010·Cancer Letters·Gaëtan JegoCarmen Garrido
Apr 8, 2011·American Journal of Respiratory and Critical Care Medicine·Ganesh RaghuUNKNOWN ATS/ERS/JRS/ALAT Committee on Idiopathic Pulmonary Fibrosis
Jul 6, 2011·The Journal of Experimental Medicine·Thomas A Wynn
Jan 5, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Guillaume WettsteinPhilippe Bonniaud
Jun 12, 2013·Annual Review of Biochemistry·Yujin E KimF Ulrich Hartl
Mar 4, 2014·Pharmacology & Therapeutics·Pierre-Simon BellayePhilippe Bonniaud
Sep 2, 2015·The European Respiratory Journal·Jonathan M SametGanesh Raghu
Dec 3, 2016·International Journal of Molecular Medicine·Gang WangXia Sun
Oct 21, 2017·Nature Reviews. Disease Primers·Fernando J MartinezAthol U Wells
May 28, 2019·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jee-Youn KimYun-Sil Lee

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