PMID: 8594028Nov 1, 1995Paper

HSP70 accumulation in tissues of heat-stressed rats is blunted with advancing age

Journal of Applied Physiology
K C KregelV Guerriero

Abstract

To determine whether aging results in reduced accumulation of the 70-kDa heat shock protein (HSP70) in response to a thermal challenge, experiments were conducted in conscious and freely moving mature (12-mo-old) and senescent (24-mo-old) male Fischer 344 rats. Rats were assigned to a euthermic control group or a nonexertionally heated group that was exposed to an ambient temperature of 42 degrees C until colonic temperature reached 41 degrees C. Samples were subsequently obtained from the liver and myocardium, and absolute levels of both the constitutive and inducible forms of HSP70 were quantitated. Heat-stressed rats had significantly elevated HSP70 levels in the liver compared with the euthermic groups. Post hoc comparisons revealed that heat stress elicited marked elevations in liver HSP70 in mature rats compared with age-matched control animals. In contrast, HSP70 values were unchanged in the senescent heated group vs. the control group. In the myocardium, heat stress produced marked increases in HSP70 levels in both the mature and senescent groups compared with age-matched control animals, with accumulation significantly blunted in the senescent vs. mature rats. Thus the increases in liver and myocardial HSP70 accumulati...Continue Reading

Citations

Aug 5, 2000·Journal of Applied Physiology·D M HallK C Kregel
Oct 3, 2001·Physiological Reviews·L H SnoeckxG J Van Der Vusse
Aug 21, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hannah J ZhangKevin C Kregel
Dec 15, 2010·Journal of Applied Physiology·Anisha A GuptePaige C Geiger
Jul 18, 2015·Clinical Physiology and Functional Imaging·Aline Bittencourt, Rossana Rosa Porto
Dec 1, 1996·Journal of Applied Physiology·D A KellyE G Noble
Jan 8, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·D M HallK C Kregel
Jan 23, 2015·Journal of Aging Research·K M RiceE R Blough
Mar 31, 1998·Environmental Health Perspectives·J S Sonneborn, S A Barbee
May 31, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·D M HallK C Kregel
Jun 5, 2003·Acta Physiologica Scandinavica·R P Taylor, J W Starnes
Aug 30, 2005·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Joseph W StarnesMichael D Delp
Jan 25, 2012·Biogerontology·Edward J CalabreseVittorio Calabrese
Mar 16, 2002·Journal of Applied Physiology·Hannah J ZhangKevin C Kregel
Sep 23, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hannah J ZhangKevin C Kregel
Jul 1, 1997·Journal of the American Geriatrics Society·A Gafni
Dec 16, 2004·Journal of Physiological Anthropology and Applied Human Science·Kee-Bum KimDong-Jun Lee
Dec 10, 2014·Nature Communications·Geeta SapraJulie R McMullen
Jul 17, 2009·The American Journal of Chinese Medicine·Fang-Tsai LeeChiang-Ting Chien
Nov 10, 2004·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Evan T Keller, Jill M Murtha
Mar 12, 2004·Mechanisms of Ageing and Development·Sam AlsburyDavid S Latchman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.