Hsp70 chaperones: cellular functions and molecular mechanism

Cellular and Molecular Life Sciences : CMLS
M P Mayer, B Bukau

Abstract

Hsp70 proteins are central components of the cellular network of molecular chaperones and folding catalysts. They assist a large variety of protein folding processes in the cell by transient association of their substrate binding domain with short hydrophobic peptide segments within their substrate proteins. The substrate binding and release cycle is driven by the switching of Hsp70 between the low-affinity ATP bound state and the high-affinity ADP bound state. Thus, ATP binding and hydrolysis are essential in vitro and in vivo for the chaperone activity of Hsp70 proteins. This ATPase cycle is controlled by co-chaperones of the family of J-domain proteins, which target Hsp70s to their substrates, and by nucleotide exchange factors, which determine the lifetime of the Hsp70-substrate complex. Additional co-chaperones fine-tune this chaperone cycle. For specific tasks the Hsp70 cycle is coupled to the action of other chaperones, such as Hsp90 and Hsp100.

References

Apr 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·K LiberekM Zylicz
Sep 1, 1989·Molecular and Cellular Biology·C M Nicolet, E A Craig
Feb 18, 1994·Science·D SchmidP Christen
May 10, 1996·The Journal of Biological Chemistry·A W Karzai, R McMacken
Jul 12, 1996·Journal of Molecular Biology·M PellecchiaK Wüthrich
Apr 15, 1997·Proceedings of the National Academy of Sciences of the United States of America·W L Kelley, C Georgopoulos
Jun 27, 1997·Journal of Molecular Biology·E V PierpaoliP Christen
May 19, 1998·Cell Stress & Chaperones·M E Cheetham, A J Caplan
Jun 30, 1998·Trends in Biochemical Sciences·W L Kelley
Nov 3, 1998·The EMBO Journal·M JäätteläM Egeblad
Dec 9, 1998·Nature·S L Rutherford, S Lindquist
Jan 5, 1999·The Journal of Biological Chemistry·S TakayamaJ C Reed
Mar 17, 1999·The EMBO Journal·G C MeachamD M Cyr
Mar 30, 1999·Experimental Cell Research·M Jäättelä
May 5, 1999·Current Biology : CB·W L Kelley
May 13, 1999·Proceedings of the National Academy of Sciences of the United States of America·T LaufenB Bukau
Jun 23, 1999·Proceedings of the National Academy of Sciences of the United States of America·K MotohashiM Yoshida
Nov 26, 1999·Proceedings of the National Academy of Sciences of the United States of America·P GoloubinoffB Bukau
Mar 14, 2000·The Journal of Biological Chemistry·J J Silberg, L E Vickery
Mar 31, 2000·Nature Structural Biology·M PellecchiaE R Zuiderweg
Apr 29, 2000·Cell·B BukauE A Craig
May 10, 2000·The Journal of Biological Chemistry·S DiamantP Goloubinoff
May 16, 2000·The Journal of Biological Chemistry·J LüdersJ Höhfeld
Jun 28, 2000·Proceedings of the National Academy of Sciences of the United States of America·K G HoffL E Vickery
Jul 6, 2000·Nature Structural Biology·M P MayerB Bukau

❮ Previous
Next ❯

Citations

Jun 14, 2008·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Andreas WielandReinhold Schirmbeck
May 27, 2011·Analytical and Bioanalytical Chemistry·Jia ZengDeirdre R Meldrum
Apr 20, 2011·Archives of Environmental Contamination and Toxicology·Haiquan ZhaoFashui Hong
Aug 3, 2013·Current Microbiology·YingYing CaiXueMei Zhang
Jul 27, 2011·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Toshiki Nagayama, Philip L Newland
Sep 27, 2005·Zeitschrift für Rheumatologie·I Melchers
Jun 17, 2006·International Journal of Legal Medicine·S MarschallM Bohnert
Jul 1, 2011·European Journal of Applied Physiology·Dmitry A SakharovAnatoly I Grigoriev
Nov 15, 2011·Parasitology Research·Jie YangZhongdao Wu
Apr 25, 2012·Protoplasma·Julie GranthamRoger Karlsson
Apr 8, 2010·Extremophiles : Life Under Extreme Conditions·Shenghao LiuXiaohang Huang
Jul 28, 2009·Functional & Integrative Genomics·Vinoth Babu V Rajan, Patrick D'Silva
Jun 17, 2009·Bulletin of Experimental Biology and Medicine·D A SakharovA G Tonevitskii
Apr 3, 2009·Clinical & Experimental Metastasis·Aparna MitraRajeev S Samant
Oct 9, 2008·Journal of Molecular Histology·Giuseppina TurturiciGabriella Sconzo
Sep 14, 2010·The Protein Journal·Yusuf TutarLütfi Tutar
Jun 19, 2010·Transgenic Research·Giampaolo BurianiSelene Baschieri
Dec 25, 2007·Journal of Molecular Neuroscience : MN·E M Hol, W Scheper
May 31, 2007·Journal of Biosciences·Richa AryaSubhash C Lakhotia
Jul 3, 2008·Cell Stress & Chaperones·Alma Rosales-HernandezJanice E A Braun
Sep 27, 2008·Cell Stress & Chaperones·Ari M ChowRobin L Anderson
Dec 3, 2009·Cell Stress & Chaperones·Tal MizrahiZeev Arad
May 25, 2010·Cell Stress & Chaperones·Manouchehr NakhjavaniTiago F Outeiro
Sep 28, 2010·Cell Stress & Chaperones·Manouchehr NakhjavaniFirouzeh Feiz
Aug 30, 2011·Cell Stress & Chaperones·Jordan Thomas Silver, Earl G Noble

❮ Previous
Next ❯

Methods Mentioned

BETA
protein folding
NMR
X-ray
nuclear magnetic resonance
nucleotide exchange
two-hybrid

Software Mentioned

WeblabViewer

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.