Hsp90 inhibition: elimination of shock and stress.

Bioorganic & Medicinal Chemistry Letters
Adam S Duerfeldt, Brian S J Blagg

Abstract

The 90 kDa heat shock proteins (Hsp90) represent a class of molecular chaperones responsible for the maturation and stabilization of many oncogenic proteins. Disrupting the ability of ATP to bind and facilitate the operation of Hsp90 has emerged as a promising approach toward cancer chemotherapeutic development. While numerous Hsp90 inhibitory scaffolds have been identified, progress through the clinic has revealed many obstacles that should be addressed in future analogue development. Recent reports of the complications, pitfalls, and downstream effects associated with Hsp90 inhibition are discussed herein, in hopes of providing a reference that can be used to guide the future design of Hsp90 inhibitory scaffolds.

References

Jun 1, 1993·Cancer Metastasis Reviews·M Belinsky, A K Jaiswal
Jan 1, 1996·Journal of Cancer Research and Clinical Oncology·K Parczyk, M R Schneider
Feb 21, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Gunay Yetik-AnacakJohn D Catravas
Oct 27, 2006·ChemMedChem·Subhabrata ChaudhuryBrian S J Blagg
Nov 1, 2006·Mini Reviews in Medicinal Chemistry·Li XiaoDouglas M Ruden
Nov 6, 2007·Current Cancer Drug Targets·Stephanie C BishopBrian S J Blagg
Jan 15, 2008·Drug Discovery Today·David B Solit, Gabriela Chiosis
Feb 5, 2008·Pharmacogenomics·Dany AnglicheauEric Thervet
Apr 1, 2008·Molecular Cancer Therapeutics·Udai BanerjiPaul Workman
May 13, 2008·Nature Reviews. Cancer·Klaus Strebhardt, Axel Ullrich
Nov 18, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Patrick G Morris, Monica N Fornier
Feb 25, 2009·ACS Chemical Biology·Chrisostomos ProdromouPeter W Piper
Apr 18, 2009·ACS Chemical Biology·Adam S Duerfeldt, Brian S J Blagg
Apr 21, 2009·Nature Reviews. Cancer·John L Nitiss
Mar 17, 2010·Drug Discovery Today·Yves L Janin

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Citations

May 10, 2011·ACS Chemical Biology·Robert L MattsBrian S J Blagg
Aug 25, 2011·Journal of Medicinal Chemistry·Bhaskar Reddy KusumaBrian S J Blagg
Apr 9, 2013·Analytical Biochemistry·Isa N CruzMin Yang
Oct 22, 2011·Bioorganic & Medicinal Chemistry Letters·Bhaskar Reddy KusumaBrian S J Blagg
Mar 6, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Dongrong ZhuJianguang Luo
Dec 7, 2013·ACS Medicinal Chemistry Letters·Xiaokai LiJason E Gestwicki

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