Hsp90 inhibitor can inhibit UV carcinogenesis

The Journal of Investigative Dermatology
Santosh K Katiyar

Abstract

Extensive exposure to solar UVR is a well-recognized etiologic factor for cutaneous non-melanoma skin cancer. In this issue of the Journal, Singh et al. show that topical treatment of the skin with 17-[allylamino]-17-demethoxygeldanamycin (17AAG), a heat-shock protein 90 (Hsp90) inhibitor, prevents UVR-induced squamous cell carcinomas (SCCs) in mice. The inhibitory effect of 17AAG on SCC was associated with the inhibition of the UVR-induced (i) hyperplastic response, (ii) Hsp90β-PKCɛ interaction, and (iii) pStat3 and pAkt expression in mouse skin.

References

Feb 19, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Matthew P GoetzCharles Erlichman
Sep 20, 2005·British Journal of Pharmacology·Csaba SõtiPéter Ferdinandy
Feb 9, 2006·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Manjeshwar S Baliga, Santosh K Katiyar
Aug 8, 2006·Seminars in Oncology·Sara B Cullinan, Luke Whitesell
Dec 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Elisabeth I HeathGlenn Liu
Aug 28, 2012·Current Pharmaceutical Design·Yoshihiko MiyataLen Neckers

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Citations

Feb 6, 2021·International Journal of Molecular Sciences·Agnieszka GęgotekElżbieta Skrzydlewska

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Methods Mentioned

BETA
transgenic

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