PMID: 11927289Apr 3, 2002Paper

Hsp90 inhibitors as novel cancer chemotherapeutic agents

Trends in Molecular Medicine
Len Neckers

Abstract

Heat shock protein 90 (Hsp90) is a molecular chaperone whose association is required for the stability and function of multiple mutated, chimeric and over-expressed signaling proteins that promote the growth and/or survival of cancer cells. Hsp90 client proteins include mutated p53, Bcr-Abl, Raf-1, Akt, ErbB2 and hypoxia-inducible factor 1 alpha (HIF-1 alpha). Hsp90 inhibitors, by interacting specifically with a single molecular target, cause the destabilization and eventual degradation of Hsp90 client proteins, and they have shown promising antitumor activity in preclinical model systems. One Hsp90 inhibitor, 17-allylaminogeldanamycin (17AAG), is currently in phase I clinical trial. Because of the chemoprotective activity of several proteins that are Hsp90 clients, the combination of an Hsp90 inhibitor with a standard chemotherapeutic agent could dramatically increase the in vivo efficacy of the therapeutic agent.

References

Jun 19, 1992·International Journal of Cancer. Journal International Du Cancer·M FerrariniC Rugarli
Apr 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J M HorowitzR A Weinberg
Aug 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·Y Xu, S Lindquist
Jun 30, 1994·Biochemical and Biophysical Research Communications·P MillerJ D Moyer
Aug 30, 1994·Proceedings of the National Academy of Sciences of the United States of America·L WhitesellL M Neckers
Aug 6, 1996·Proceedings of the National Academy of Sciences of the United States of America·M V BlagosklonnyL Neckers
Aug 14, 1996·Biochemical and Biophysical Research Communications·M J SlepianL Whitesell
Nov 8, 1996·The Journal of Biological Chemistry·Y FangA J Caplan
Dec 10, 1996·Proceedings of the National Academy of Sciences of the United States of America·C SchneiderF U Hartl
Jul 25, 1997·The Journal of Biological Chemistry·B Segnitz, U Gehring
Sep 29, 1998·Biochemical Pharmacology·T Scheibel, J Buchner
Dec 9, 1998·Nature·S L Rutherford, S Lindquist
Apr 10, 1999·Genes & Development·S E HoltM A White
Oct 27, 1999·The Journal of Thoracic and Cardiovascular Surgery·D M NguyenD S Schrump
Feb 3, 2000·Journal of the National Cancer Institute·M G MarcuL Neckers
Sep 20, 2000·Proceedings of the National Academy of Sciences of the United States of America·S SatoT Tsuruo
Jan 9, 2001·Nature Cell Biology·G C MeachamD M Cyr
Apr 11, 2001·Bioorganic & Medicinal Chemistry Letters·G ChiosisL Sepp-Lorenzino
Jun 8, 2001·Journal of Chromatography. B, Biomedical Sciences and Applications·E B AgnewC H Takimoto
Apr 4, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Julie L EisemanMerrill J Egorin

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Citations

Feb 14, 2012·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Samuel K ShimpM Nichole Rylander
Jun 3, 2006·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Masahiro WazaGen Sobue
Jul 22, 2005·Cancer Immunology, Immunotherapy : CII·Øystein BruserudBjørn Tore Gjertsen
Jul 13, 2007·Cancer Chemotherapy and Pharmacology·Jon PattersonEmmanuel Normant
Nov 12, 2005·Journal of Cancer Research and Clinical Oncology·Megumi SenjuEisaburo Sueoka
Jun 30, 2006·Cellular and Molecular Neurobiology·Richard M Weinshilboum
May 5, 2009·Molecular and Cellular Biochemistry·Xu SunHe-Yao Wang
May 31, 2007·Journal of Biosciences·Len Neckers
Mar 17, 2010·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Alejandra Giménez Ortiz, Joaquín Montalar Salcedo
Aug 1, 2013·Pathology Oncology Research : POR·J M Patki, S S Pawar
Mar 17, 2004·Biochimica Et Biophysica Acta·Amere Subbarao SreedharPéter Csermely
Feb 18, 2004·International Journal of Radiation Oncology, Biology, Physics·Mina D MarmorYosef Yarden
Jan 31, 2004·International Journal of Radiation Oncology, Biology, Physics·C Norman Coleman
Feb 1, 2003·Biochemical and Biophysical Research Communications·Noriko SatoTadashi Matsuda
Oct 29, 2003·Experimental Gerontology·Csaba Soti, Péter Csermely
Oct 22, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P Workman
Oct 18, 2003·Seminars in Cancer Biology·Quinn L DeverauxGarret M Hampton
Apr 12, 2003·Drug Discovery Today·David P Lane, Ted R Hupp
Apr 5, 2003·Cancer Cell·Jennifer S IsaacsLen Neckers
Sep 29, 2011·ACS Chemical Biology·Veronica C ArdiShelli R McAlpine
May 31, 2012·Journal of the American Chemical Society·Adam S DuerfeldtBrian S J Blagg
Dec 18, 2009·Journal of Medicinal Chemistry·Leslie D AlexanderShelli R McAlpine
May 1, 2012·Cellular & Molecular Immunology·Samuel K ShimpChristopher M Reilly
May 11, 2004·Nature Biotechnology·Peter M Smith-JonesSteven M Larson
Mar 4, 2009·Nature Cell Biology·Cam Patterson, Sarah Ronnebaum
Sep 5, 2002·Nature Reviews. Drug Discovery·Patrick Chène
Oct 20, 2009·Nature Structural & Molecular Biology·Shinji TsutsumiLen Neckers
Feb 23, 2008·Proceedings of the National Academy of Sciences of the United States of America·Chad A DickeyLeonard Petrucelli
Oct 9, 2008·Proceedings of the National Academy of Sciences of the United States of America·Akihiro YanoLen Neckers
Nov 26, 2009·Proceedings of the National Academy of Sciences of the United States of America·Elana S EhrlichXiao-Fang Yu
Jul 17, 2013·Proceedings of the National Academy of Sciences of the United States of America·Tamina Seeger-NukpezahErica A Golemis

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