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Hsp90 promotes kinase evolution

bioRxiv

Jun 19, 2014

Jennifer LachowiecChristine Queitsch

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Abstract

Heat-shock protein 90 (Hsp90) promotes the maturation and stability of its client proteins, including many kinases. In doing so, Hsp90 may allow its clients to accumulate mutations as previously proposed by the capacitor hypothesis. If true, Hsp90 clients should show increased evolution...read more

Mentioned in this Paper

Anatomical Maturation
Gene Expression
Amino Acid [EPC]
HSP90AA1 wt Allele
Heat shock proteins
Molecular Chaperones
Staphylococcal Protein A
Base Sequence
Biologic Development
MRNA Maturation
5
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  • Hsp90 promotes kinase evolution

    bioRxiv

    Jun 19, 2014

    Jennifer LachowiecChristine Queitsch

    PMID: 990006411

    DOI: 10.1101/006411

    Abstract

    Heat-shock protein 90 (Hsp90) promotes the maturation and stability of its client proteins, including many kinases. In doing so, Hsp90 may allow its clients to accumulate mutations as previously proposed by the capacitor hypothesis. If true, Hsp90 clients should show increased evolution...read more

    Mentioned in this Paper

    Anatomical Maturation
    Gene Expression
    Amino Acid [EPC]
    HSP90AA1 wt Allele
    Heat shock proteins
    5

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