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Hsp90 promotes kinase evolution

bioRxiv

Jun 19, 2014

Jennifer LachowiecChristine Queitsch

Abstract

Heat-shock protein 90 (Hsp90) promotes the maturation and stability of its client proteins, including many kinases. In doing so, Hsp90 may allow its clients to accumulate mutations as previously proposed by the capacitor hypothesis. If true, Hsp90 clients should show increased evolution...read more

Mentioned in this Paper

Molecular Chaperones
HSP90 Heat-Shock Proteins
HSP90AA1 gene
Nucleotides
Phosphotransferases
Protein KINASE
Shapes
Staphylococcal Protein A
Base Sequence
Amino Acid [EPC]
5
1
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Hsp90 promotes kinase evolution

bioRxiv

Jun 19, 2014

Jennifer LachowiecChristine Queitsch

PMID: 990006411

DOI: 10.1101/006411

Abstract

Heat-shock protein 90 (Hsp90) promotes the maturation and stability of its client proteins, including many kinases. In doing so, Hsp90 may allow its clients to accumulate mutations as previously proposed by the capacitor hypothesis. If true, Hsp90 clients should show increased evolution...read more

Mentioned in this Paper

Molecular Chaperones
HSP90 Heat-Shock Proteins
HSP90AA1 gene
Nucleotides
Phosphotransferases
Protein KINASE
Shapes
Staphylococcal Protein A
Base Sequence
Amino Acid [EPC]
5
1

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Paper Details
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  • finger pointing at paper

    References currently unavailable

    We're still populating references for this paper, please check back later.
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