hTERT mediates gastric cancer metastasis partially through the indirect targeting of ITGB1 by microRNA-29a.

Scientific Reports
Bing HeShi-Ming Yang

Abstract

Human telomerase reverse transcriptase (hTERT) plays a key role in tumor invasion and metastasis, but the mechanism of its involvement in these processes is not clear. The purpose of this study is to investigate the possible molecular mechanism of hTERT in the promotion of gastric cancer (GC) metastasis. We found that the up-regulation of hTERT in gastric cancer cells could inhibit the expression of miR-29a and enhance the expression of Integrin β1 (ITGB1). In addition, the invasive capacity of gastric cancer cells was also highly increased after hTERT overexpression. Our study also found that the restoration of miR-29a suppressed the expression of ITGB1 and inhibited GC cell metastasis both in vitro and in vivo. Taken together, our results suggested that hTERT may promote GC metastasis through the hTERT-miR-29a-ITGB1 regulatory pathway.

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Citations

Mar 30, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·V G Manasa, S Kannan
Dec 9, 2017·Bioscience Reports·Jin-Yan WangJin-Hai Tang
May 24, 2019·Bioengineered·Jinfeng MaJisheng Gao
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Apr 5, 2018·International Journal of Molecular Sciences·Ammad Ahmad FarooqiBaojun Xu
Jul 4, 2020·Journal of Gastrointestinal Cancer·Sogand VahidiAli Akbar Samadani
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Jan 8, 2021·Journal of Gastrointestinal Cancer·Sogand Vahidi, Ali Akbar Samadani

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Datasets Mentioned

BETA
SGC7901

Methods Mentioned

BETA
transfection
fluorescence imaging
FACS
PCR
Protein Assay
Assay

Software Mentioned

GraphPad
Image
Prism
Spectrum Mill proteomics Workbench Rev
Pro Plus

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