HTLV-I associated myelopathy/tropical spastic paraparesis in a 7-year-old boy associated with infective dermatitis

Journal of the Neurological Sciences
Maria de Fátima S P de OliveiraFabricio Almeida

Abstract

HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a chronic myelopathy characterized by a slowly progressive spastic paraparesis and sphincter disturbances beginning in adulthood. Only eight well-documented cases occurring in childhood and adolescence have been described. Infective dermatitis associated to the HTLV-I (IDH) is a chronic eczema of childhood occurring in vertically infected carriers. Here we describe a 7-year-old boy with HAM/TSP and IDH. The neurological manifestations were spastic gait, hyperreflexia of lower limbs, clonus and bilateral Babinski's sign. High levels of HTLV-I antibodies in the serum and in the cerebrospinal fluid were observed. The association of these two diseases and the early onset of HAM/TSP are probably related to a strong humoral anti-HTLV-I response.

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Citations

May 13, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Maria de Fatima S P de OliveiraAchilea L Bittencourt
Jul 20, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Janeusa Rita L PrimoAchiléa L Bittencourt
Aug 13, 2013·PLoS Neglected Tropical Diseases·Jordana Grazziela Alves Coelho-dos-ReisOlindo Assis Martins-Filho
Apr 18, 2013·PLoS Pathogens·Nicolas A GilletCharles R M Bangham
Aug 10, 2010·Journal of the American Academy of Dermatology·Robert Lee, Robert A Schwartz
Apr 21, 2009·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·M E Pérez GutiérrezEsmelda Montalbán
Jul 3, 2009·International Journal of Dermatology·Luciana MaragnoJosé Antônio Sanches
Jul 26, 2011·International Journal of Dermatology·Masahiro AmanoFrancisco A Kerdel
Jun 19, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Cinthya Maria Neves VarandasAchiléa L Bittencourt
Nov 21, 2012·Experimental Dermatology·Neilia-Kay McGillVincent Piguet

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