HTLV-III infection in brains of children and adults with AIDS encephalopathy

Science
G M ShawJ E Groopman

Abstract

Unexplained debilitating dementia or encephalopathy occurs frequently in adults and children with the acquired immune deficiency syndrome (AIDS). Brains from 15 individuals with AIDS and encephalopathy were examined by Southern analysis and in situ hybridization for the presence of human T-cell leukemia (lymphotropic) virus type III (HTLV-III), the virus believed to be the causative agent of AIDS. HTLV-III DNA was detected in the brains of five patients, and viral-specific RNA was detected in four of these. In view of these findings and the recent demonstration of morphologic and genetic relatedness between HTLV-III and visna virus, a lentivirus that causes a chronic degenerative neurologic disease in sheep, HTLV-III should be evaluated further as a possible cause of AIDS encephalopathy.

Citations

Sep 1, 1996·Reviews in Medical Virology·R K FujimuraP Shapshak
Jun 1, 1991·Annals of Neurology·C WileyR Terry
Aug 1, 1991·Annals of Neurology·P T MerrillD B Clifford
Apr 1, 1992·Annals of Neurology·W R TyorD E Griffin
Jan 1, 1994·Annals of Neurology·R T Johnson
Oct 1, 1995·Annals of Neurology·C Wiley, C L Achim
Jul 17, 2001·Microscopy Research and Technique·J D Glass, S L Wesselingh
Mar 17, 2001·NMR in Biomedicine·H K PattonD J Benos
Jan 1, 1992·Medical Microbiology and Immunology·S RossolK H Meyer zum Büschenfelde
Jun 1, 1987·Journal of Neurology·P A Fischer, W Enzensberger
Jun 1, 1986·Journal of Neurology·R AckermannR Jürgens
Jan 1, 1993·Journal of Neurology·M FialaH V Vinters
Jan 1, 1993·International Journal of Legal Medicine·Eva Neuen-JacobW Wechsler
Jan 4, 1988·Klinische Wochenschrift·S PoserK Felgenhauer
Dec 1, 1989·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·P B WilloughbyJ D Folds
Dec 1, 1988·Italian Journal of Neurological Sciences·L OrtonaG Ventura
Apr 1, 1988·Italian Journal of Neurological Sciences·B CostaA Fiaschi
Jun 16, 2000·Journal of Urban Health : Bulletin of the New York Academy of Medicine·J Booss
Jan 1, 1991·Journal of General Internal Medicine·H Hollander
Dec 1, 1986·Journal of the Neurological Sciences·S RosembergA M Tsanaclis
May 1, 1987·Journal of the Neurological Sciences·I ElovaaraJ Lähdevirta
Dec 1, 1990·Journal of the Neurological Sciences·T MathiesenB Wahren
Jun 1, 1994·Journal of the Neurological Sciences·R T Johnson
Feb 1, 1994·Journal of the Neurological Sciences·H J von GiesenH J Freund
Jan 1, 1987·Seminars in Roentgenology·G SzeT H Newton
Jan 1, 1987·Seminars in Roentgenology·D A Nyberg, M P Federle
Jun 1, 1987·Veterinary Immunology and Immunopathology·J E HeidrichR E Smith
May 1, 1989·Veterinary Immunology and Immunopathology·J I MullinsM L Poss
Jan 1, 1986·Cancer Genetics and Cytogenetics·M E Harper, L M Marselle
Dec 1, 1988·Journal of Neuroimmunology·P A Fischer, W Enzensberger
Aug 1, 1987·Journal of Virological Methods·J GoudsmitM Bakker
Sep 1, 1988·Journal of Virological Methods·N L SeibelI R Kirsch
Dec 1, 1987·American Family Physician·D B Clifford
Jan 1, 1986·Progress in Neuro-psychopharmacology & Biological Psychiatry·R F De Estable-PuigC Radouco-Thomas
Jan 1, 1985·Progress in Neurobiology·H J Markowitsch, M Pritzel
Jul 1, 1989·Diagnostic Microbiology and Infectious Disease·P B WilloughbyJ D Folds
May 1, 1988·Gene Analysis Techniques·A B RabsonH E Gendelman
Oct 1, 1991·Schizophrenia Research·M A CoggianoH Kulaga
Aug 17, 1985·Lancet·C S ThomasC P Farthing
Feb 11, 1989·Lancet·P L LantosJ R Tighe
Jul 1, 1989·Ophthalmology·D A JabsJ G Bartlett
Feb 5, 2002·Archives of Medical Research·Laura Reyes-ContrerasGabriel Romo-Gutiérrez
Nov 18, 1998·International Journal of Immunopharmacology·J L TangS Specter
Mar 6, 2003·Neurologic Clinics·A L Belman
Sep 16, 2000·Trends in Microbiology·R W Price
Aug 1, 1990·Psychological Medicine·M Maj
May 20, 2003·Psychiatry and Clinical Neurosciences·Enrique Vázquez-JustoMaria J Ferraces Otero
Aug 1, 1985·The New England Journal of Medicine·P M HoffmanF W Ruscetti
Dec 12, 1985·The New England Journal of Medicine·P H Black
Apr 10, 1986·The New England Journal of Medicine·R Katzman
Jul 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·B H HahnF Wong-Staal
Nov 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·R M RuprechtS Broder
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·M A GondaR V Gilden
Sep 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·C WileyM B Oldstone
Nov 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·S M HammerR M Rose
Dec 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·S PahwaC W Saxinger
Feb 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·M E HarperF Wong-Staal
May 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·Cecilia Cheng-MayerJ A Levy
Jun 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·R PahwaS Pahwa
Jun 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·J GoudsmitD C Gajdusek
Mar 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·B YoffeF B Hollinger
Apr 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·C RosenW Haseltine
Aug 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·A SrinivasanR A Robinson
Nov 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·Cecilia Cheng-MayerJ A Levy
Feb 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·P H Duesberg
Feb 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·R GentzC Rosen
Mar 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·M A TillE S Vitetta
May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·D J EilbottB Weiser
May 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·B WeiserH Burger
Jul 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J B LawrenceR H Singer
May 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·H TadaK Khalili
Mar 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·A M SteffanA Kirn
Nov 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·A V MosesJ A Nelson
Jul 19, 1994·Proceedings of the National Academy of Sciences of the United States of America·N K HeinzingerM Emerman
Jan 18, 1994·Proceedings of the National Academy of Sciences of the United States of America·D J BenosE N Benveniste
Oct 1, 1990·Journal of Clinical and Experimental Neuropsychology·A GibbsS C Bowden
Jan 1, 1987·AIDS Research and Human Retroviruses·S W RostadJ K McDougall
Dec 1, 1989·AIDS Research and Human Retroviruses·J YournoF Wong-Staal
Dec 1, 1989·AIDS Research and Human Retroviruses·K LjunggrenE M Fenyö
Nov 11, 1992·AIDS Research and Human Retroviruses·I J KoralnikG Franchini
Dec 1, 1994·AIDS Research and Human Retroviruses·W C HatchW D Lyman
Jan 1, 1995·AIDS Research and Human Retroviruses·C VellutiniP Filippi
Oct 29, 2008·Evidence-based Complementary and Alternative Medicine : ECAM·Mamdooh Ghoneum, Magda Shaheen
Mar 1, 1995·Journal of the American Academy of Child and Adolescent Psychiatry·M CeseñaR J Steingard
May 1, 1996·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·J R TrujilloM Essex
Apr 3, 1998·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·L A PantherL Corey
Mar 17, 1999·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·Christian EggersH J Stellbrink
Mar 1, 1991·Acta Pathologica Japonica·H Budka
Dec 1, 1995·Australian and New Zealand Journal of Medicine·S M Crowe
Mar 1, 1993·The European Journal of Neuroscience·P M SweetnamJ W Ferkany
Jan 1, 1992·Acta Neurologica Scandinavica. Supplementum·E S Tolosa, R Alvarez
Oct 29, 1993·Annals of the New York Academy of Sciences·D W DicksonK M Weidenheim
Oct 29, 1993·Annals of the New York Academy of Sciences·A L Belman
Jun 6, 1994·Annals of the New York Academy of Sciences·R T Johnson
Jun 6, 1994·Annals of the New York Academy of Sciences·F H Michaels, R C Gallo
Jan 1, 1997·Brain Pathology·M M Esiri
Mar 1, 2003·Journal of Virology·Jana J von LindernWilliam A O'Brien
May 10, 1986·British Medical Journal·J GoudsmitH J Van der Helm
Aug 23, 1986·British Medical Journal·C A Carne, M W Adler
Sep 30, 1989·BMJ : British Medical Journal·P PortegiesJ Goudsmit
Jul 1, 1986·Journal of Neurology, Neurosurgery, and Psychiatry·A E FarkashG C Hotson
Feb 1, 1987·Journal of Neurology, Neurosurgery, and Psychiatry·A Steck, J C de Flaugergues
Aug 1, 1988·Journal of Neurology, Neurosurgery, and Psychiatry·K S BukasaJ Sonnet
May 1, 1989·Journal of Neurology, Neurosurgery, and Psychiatry·D G WalkerP L McGeer
Aug 1, 1990·Journal of Neurology, Neurosurgery, and Psychiatry·P G Kennedy
May 12, 1998·Journal of Neurology, Neurosurgery, and Psychiatry·I L SimoneP Livrea
Apr 1, 1997·Molecular Pathology : MP·S Swingler
Mar 1, 1988·Postgraduate Medical Journal·P G Kennedy
Jun 1, 1989·Genitourinary Medicine·C A CarneM J Harrison
Oct 1, 1989·Genitourinary Medicine·M PezzellaE Mannella
May 1, 1986·The Journal of Clinical Investigation·D D HoM S Hirsch
Jan 1, 1986·Journal of Community Health Nursing·W Goff, P McDonough
Dec 1, 1986·The Australian and New Zealand Journal of Psychiatry·H A Whiteford, J G Csernansky
May 12, 2011·Pathology Research International·Tee U LangLiron Pantanowitz
Jul 15, 1988·American Journal of Ophthalmology·P L FarrellA Mamelok
Oct 15, 1988·American Journal of Ophthalmology·L M HamedS L Galetta
Dec 1, 1986·European Journal of Pediatrics·T JonckheerH Taelman
Jun 1, 1989·Italian Journal of Neurological Sciences·M C Dal Canto
Oct 15, 1985·American Journal of Ophthalmology·J S PeposeG N Holland
Oct 9, 2014·Der Nervenarzt·Christian Eggers, für die Deutsche Neuro-AIDS-Arbeitsgemeinschaft (DNAA)
Feb 23, 2002·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·C PowerR T Johnson
Jun 4, 1998·Journal of Neuroimmunology·K GoodkinA M Kumar
May 11, 1991·Lancet·I P EverallP L Lantos
Dec 1, 1989·The Japanese Journal of Psychiatry and Neurology·I KobayashiA Masuda
Mar 16, 1987·Klinische Wochenschrift·T WeberK Felgenhauer
Jan 1, 1986·Scandinavian Journal of Infectious Diseases·L HagbergG Norkrans
Feb 1, 1987·The International Journal of Neuroscience·J M HillC B Pert
Feb 1, 1987·The International Journal of Neuroscience·M H UltmannH J Cohen
May 1, 1986·Immunological Investigations·D E Mosier
Jan 1, 1988·Critical Reviews in Clinical Laboratory Sciences·S S Levinson, G A Denys
Jul 1, 1989·Journal of Pharmaceutical Sciences·B A PatelF D Boudinot
Jun 1, 1989·Perceptual and Motor Skills·M L FitzgibbonK Sheridan
Jun 1, 1988·Pathology, Research and Practice·G Gosztonyi, J Cervós-Navarro
Aug 1, 1986·Psychosomatics·J W DilleyS L Batki
Apr 1, 1986·Psychosomatics·M A Cohen, H W Weisman
Dec 1, 1986·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·G AnnerothD P Lynch
Mar 1, 1987·Annales De L'Institut Pasteur. Immunology·A S Fauci, H C Lane
Nov 3, 1998·Pediatric Annals·G B ZuckermanE E Conway
May 1, 1988·Pediatric Annals·G B Scott
Jun 1, 1990·Journal of the American Academy of Dermatology·D H Gabuzda
Mar 1, 1987·Journal of the American Academy of Dermatology·M H KaplanS Pahwa
Jan 1, 1994·Advances in Neuroimmunology·D E BrennemanJ M Hill
Mar 29, 2007·Brain Pathology·Francesco ScaravilliF Gray
Jan 1, 1995·Advances in Neuroimmunology·M YoshiokaS Nakamura
Apr 1, 1992·Current Problems in Pediatrics·F J Indacochea, G B Scott
Oct 30, 1986·Biochemical and Biophysical Research Communications·J A BilelloS R Max
Nov 29, 1994·Biochemical Pharmacology·H J KangJ L Au
Jul 28, 1986·The American Journal of Medicine·I H Grant, D Armstrong
Apr 1, 1986·Biological Psychiatry·T P BeresfordR C Hall
Jul 1, 1988·Virology·J A NelsonC Wiley
Oct 1, 1993·Medical Hypotheses·D Siefkes
Feb 1, 1986·Microbial Pathogenesis·Ashley T Haase
Oct 1, 1985·General Hospital Psychiatry·D L WolcottR O Pasnau
May 1, 1986·Comprehensive Psychiatry·R H GabelR A O'Connell
Sep 1, 1989·Journal of Veterinary Pharmacology and Therapeutics·R J WilliamsJ E Dahlberg
Jan 1, 1988·Annals of the New York Academy of Sciences·S BakshiL Z Cooper
Feb 1, 1987·Annals of Neurology·R T Johnson, J C McArthur
Dec 1, 1986·Law, Medicine & Health Care : a Publication of the American Society of Law & Medicine·L Gostin
May 1, 1987·Annals of Neurology·T Pumarola-SuneR W Price
Sep 1, 1988·Acta paediatrica Scandinavica·P A TovoG Gajno
Jun 1, 1986·Annals of Neurology·B A NaviaR W Price
Jun 1, 1986·Annals of Neurology·B A NaviaR W Price
Jan 1, 1988·Journal of Electron Microscopy Technique·M A Gonda
Dec 1, 1987·Annals of Neurology·D A RottenbergR W Price
Dec 1, 1987·Immunological Reviews·W L FarrarM Vinocour
Mar 1, 1992·Baillière's Clinical Obstetrics and Gynaecology·F M Kaoma, G B Scott
May 1, 1987·Journal of the American Geriatrics Society·R J Moss, S Miles
Jan 1, 1988·Acta Neurologica Scandinavica·S Helweg-LarsenH Permin
Aug 1, 1986·Acta Neurologica Scandinavica·A De RossiL Chieco-Bianchi
Dec 1, 1986·Acta Neurologica Scandinavica·S Helweg-LarsenP Arlien-Søborg
Jun 1, 1986·Acta Neurologica Scandinavica·B M SinghG P Wormser
Feb 1, 1989·Acta Neurologica Scandinavica·I ElovaaraJ Lähdevirta
Jan 1, 1989·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·A PorwitP Biberfeld
Jan 1, 1987·Journal of Neuroscience Research
Jan 1, 1987·Annals of the New York Academy of Sciences·C Gurgo, R C Gallo
Sep 1, 1988·Neuropathology and Applied Neurobiology·M F Gonzales, R L Davis
Sep 1, 1988·Neuropathology and Applied Neurobiology·F GrayJ Poirier
Jan 1, 1988·Annals of Neurology·R S JanssenL B Schonberger
Jan 1, 1988·Annals of Neurology·D R RubinowH C Lane
Jan 1, 1988·Annals of Neurology·R W PriceM Rosenblum
Jan 1, 1988·Annals of Neurology·P E B Rodgers-JohnsonD C Gajdusek
Apr 1, 1989·Annals of Neurology·J M HarouseF Gonzalez-Scarano
Jan 1, 1988·Acta Neurologica Scandinavica. Supplementum·J R Berger
May 1, 1988·Annals of Neurology·S M de la MonteA K Bhan
Jul 1, 1987·Neuropathology and Applied Neurobiology·A G DalgleishH E Webb
Feb 1, 1992·Oral Surgery, Oral Medicine, and Oral Pathology·G Ficarra
Jun 1, 1988·Oral Surgery, Oral Medicine, and Oral Pathology·A H Friedlander, R J Arthur
Nov 1, 1989·Seminars in Oncology Nursing·D Vlahov
Sep 1, 1993·Journal of Hepatology·C HoussetC Brechot
Jan 1, 1989·Scandinavian Journal of Infectious Diseases. Supplementum·H Gaines
Mar 10, 2015·Journal of Neurovirology·Mamata MishraUdaykumar Ranga
Oct 9, 1999·The American Journal of Pathology·S V WestmorelandA A Lackner
Oct 16, 2016·Science·R C Gallo
Jul 3, 1986·The New England Journal of Medicine
Jul 30, 1987·The New England Journal of Medicine·D D HoJ C Kaplan
Dec 24, 1987·The New England Journal of Medicine·R J PomerantzM S Hirsch
Jan 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K HosodaM Ohto
Jan 14, 2010·Arquivos de neuro-psiquiatria·Fidias E Leon-SarmientoNash N Boutros
Nov 14, 1985·Nature·H KoprowskiR C Gallo
Jul 10, 1986·Nature·Ashley T Haase
Oct 3, 1985·Nature·F Wong-Staal, R C Gallo
Jul 1, 1994·Survey of Ophthalmology·T R Hedges
Mar 1, 1990·Annals of Emergency Medicine·E TerwilligerW Haseltine
Mar 29, 2005·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Marilyn S SmithO Narayan
Jan 1, 1987·Journal of Substance Abuse Treatment·M H Kaplan
Jul 1, 1986·Acta Radiologica: Diagnosis·B BrunJ Praestholm
Oct 1, 1992·Journal of Child Neurology·D K Burns
Feb 1, 1993·Journal of Learning Disabilities·F D ArmstrongT P Swales
Jan 1, 1991·Clinical EEG (electroencephalography)·A ParisiL Minoli
Jan 1, 1988·Clinical EEG (electroencephalography)·D H GabuzdaK H Chiappa
Jul 8, 2005·Journal of Leukocyte Biology·Amanda BrownCecilia Cheng-Mayer
Jan 1, 1986·International Journal of Psychiatry in Medicine·W M Detmer, F G Lu
Apr 2, 1987·Nature·R C Gallo, L Montagnier
Feb 4, 1987·Nature·H Mitsuya, S Broder
Jun 1, 1989·Journal of Medical Virology·J R HarrisG Tovey
Feb 1, 1988·Bioscience Reports·R F GarryD A Bostick
Aug 23, 1986·British Medical Journal·R Mills
May 1, 1988·The British Journal of Psychiatry : the Journal of Mental Science·N BuhrichE Freed
Jan 1, 1988·Pediatric Radiology·D B PriceA L Rose
Feb 21, 1985·The New England Journal of Medicine·S H LandesmanS H Weiss
Mar 1, 1986·Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section A, Pathology·C F LindboeA C Løken
May 1, 1996·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·P BrouwersP Pierce
Apr 1, 1989·Scottish Medical Journal·P G KennedyI Bone
Mar 1, 1988·Annals of Tropical Paediatrics·M L Blokzijl
Aug 1, 1985·Journal of the Royal Society of Medicine·J Seale
Jan 1, 1991·Current Eye Research·H B QaviD E Lewis
Jan 1, 1986·Seminars in Surgical Oncology·K V Rolston, G P Bodey
Nov 1, 1987·The British Journal of Psychiatry : the Journal of Mental Science·C S Thomas, E Szabadi
Feb 1, 1989·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·R G Curless
Mar 1, 1989·Arquivos de neuro-psiquiatria·M ScaffP E Marchiori
Jan 1, 1990·American Journal of Human Biology : the Official Journal of the Human Biology Council·P E B Rodgers-JohnsonD C Gajdusek
Sep 1, 2018·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Celina AbreuJanice E Clements
Oct 1, 1986·The American Journal of Orthopsychiatry·Edwin V Valdiserri
Jan 1, 1988·Archives of Virology·A SrinivasanR Anand
Oct 1, 1986·Anaesthesia·K G Lee, N Soni
May 2, 1985·Klinische Wochenschrift·R HehlmannR Kurth
May 1, 1995·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·C Power, R T Johnson
Jun 2, 2017·Journal of Neurology·Christian EggersGerman Association of Neuro-AIDS und Neuro-Infectiology (DGNANI)
Jan 31, 2020·Journal of Extracellular Vesicles·Paula Soledad PérezMatías Ostrowski
Sep 1, 1987·The Australian and New Zealand Journal of Psychiatry·N Buhrich, D A Cooper
Nov 1, 1987·The British Journal of Psychiatry : the Journal of Mental Science·T W Fenton
May 18, 1992·The Medical Journal of Australia·M C HingD A Cooper

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Acquired Immunodeficiency Syndrome
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