Htr2c Splice Variants and 5HT2C R-Mediated Appetite

Trends in Endocrinology and Metabolism : TEM
Anthony R Isles

Abstract

Serotonin 2C receptor (5HT2CR) exists as different isoforms as a result of alternate splicing. A truncated variant (5HT2CR-trunc) has no canonical receptor function and yet shows robust expression levels throughout the brain. Recent work has demonstrated the biochemical role of this isoform and how altering levels of 5HT2CR-trunc leads to changes in behaviour.

Citations

Feb 24, 2018·International Journal of Molecular Sciences·Chi-Ming WongMabel Yin-Chun Yau
Apr 11, 2019·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Trevor HumbyLawrence S Wilkinson

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