Abstract
The purpose of the present study was to examine the dose-response relationship and the therapeutic time window for the synthetic nonpsychotropic cannabinoid (HU-211) as a neuroprotective agent in transient, severe forebrain ischemia in the rat. Adult Sprague-Dawley rats were subjected to 20 min common carotid artery occlusion (CCAo) 24 h after coagulation of both vertebral arteries. Thirty minutes after the onset of CCAo, rats received an iv injection of HU-211 2, 4, or 8 mg/kg in HPCD (n = 12, 18, and 11, respectively), or the appropriate vehicle (n = 20). Neurological signs were scored daily for 3 d following ischemia. A significant improvement (p < 0.01, Kruskal-Wallis nonparametric test, followed by Mann-Whitney U-test, p < 0.05) of neurological deficits by the 4 mg/kg dose of HU-211, was observed 24, 48, and 72 h after insult. On the third day post-CCAo, the rat brain was taken for histopathological evaluation of the CA-1 sector of the hippocampus. Counts of viable neurons in the hippocampal CA1 field showed significantly more live cells in the HU-211 (4 mg/kg) treated animals (P < 0.001, ANOVA followed by Duncan's post-hoc test, p < 0.05). The drug was equally effective when given 30 and 60 min after ischemia, but neuropr...Continue Reading
References
May 1, 1979·Stroke; a Journal of Cerebral Circulation·W A Pulsinelli, J B Brierley
Feb 1, 1992·Stroke; a Journal of Cerebral Circulation·K Suyama
Feb 1, 1992·Stroke; a Journal of Cerebral Circulation·Y UedaL Symon
Jan 31, 1992·Brain Research·E Le PeilletB S Meldrum
Nov 1, 1992·Stroke; a Journal of Cerebral Circulation·J A OostveenL R Williams
Feb 1, 1992·Stroke; a Journal of Cerebral Circulation·E Merlo PichL F Agnati
Feb 1, 1992·Stroke; a Journal of Cerebral Circulation·F WahlR G Boulu
Aug 1, 1992·Stroke; a Journal of Cerebral Circulation·A UmemuraH Nagai
Jan 1, 1990·Annual Review of Neuroscience·D W Choi, S M Rothman
Jun 1, 1990·Clinical Neuropharmacology·G W Albers
Oct 1, 1990·Trends in Pharmacological Sciences·J WillettsJ D Leander
May 1, 1990·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J H Swan, B S Meldrum
Feb 1, 1986·Annals of Neurology·S M Rothman, J W Olney
Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J J FeigenbaumM Sokolovsky
Jul 1, 1989·Stroke; a Journal of Cerebral Circulation·R BustoM D Ginsberg
Aug 1, 1989·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·M R Rod, R N Auer
Dec 1, 1989·Stroke; a Journal of Cerebral Circulation·M D Ginsberg, R Busto
Jul 3, 1989·Neuroscience Letters·R BustoM D Ginsberg
Jul 24, 1989·Brain Research·L A Mudrick, K G Baimbridge
May 22, 1989·Brain Research·H Onodera, K Kogure
Jan 1, 1985·Progress in Brain Research·W A Pulsinelli
Oct 1, 1988·Neuron·D W Choi
Jul 1, 1988·Stroke; a Journal of Cerebral Circulation·W A Pulsinelli, A M Buchan
Sep 15, 1988·Experientia·R MechoulamP Consroe
Dec 1, 1987·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R BustoM D Ginsberg
Feb 3, 1986·Life Sciences·C CapdevilleR G Boulu
Nov 16, 1984·Science·R P SimonB S Meldrum
Nov 1, 1984·Journal of Neurochemistry·H BenvenisteN H Diemer
May 1, 1984·Stroke; a Journal of Cerebral Circulation·B T VolpeH P Davis
May 1, 1982·Annals of Neurology·W A PulsinelliF Plum
Jun 1, 1994·Thorax·L K GreenL C Alpert
Oct 1, 1994·Molecular and Chemical Neuropathology·A Bar-JosephA Biegon
Nov 12, 1993·Neuroscience Letters·V NadlerM Sokolovsky
Sep 17, 1993·Brain Research·V NadlerM Sokolovsky
Dec 13, 1993·Neuroreport·N EshharA Biegon
Aug 6, 1993·Brain Research·K B MackayJ McCulloch
Jan 1, 1993·Journal of Neurotrauma·E ShohamiR Mechoulam
May 1, 1993·Stroke; a Journal of Cerebral Circulation·J A ClemensJ A Panetta
Citations
Mar 4, 2000·Brain Research·D F LouwG R Sutherland
Jan 10, 1998·European Journal of Pharmacology·S StriemA Biegon
Apr 15, 1999·Journal of the Neurological Sciences·R R LekerH Ovadia
Jul 13, 2001·Pharmacology & Therapeutics·A C Porter, C C Felder
Aug 17, 2002·Pharmacology & Therapeutics·Julián RomeroJavier Fernández-Ruiz
Sep 14, 2006·Pharmacological Reviews·Pál PacherGeorge Kunos
Aug 26, 2014·Future Oncology·Ichiro Nakano
Mar 22, 2006·Expert Opinion on Investigational Drugs·Ben A BahrAlexandros Makriyannis
Oct 22, 2002·Expert Opinion on Investigational Drugs·Robert I Grundy
Dec 8, 1995·Brain Research·L BelayevM D Ginsberg
Jan 22, 2003·Vision Research·M Zalish, V Lavie
Jan 1, 2000·Addiction Biology·R G Pertwee
Dec 1, 1995·Stroke; a Journal of Cerebral Circulation·L BelayevM D Ginsberg
Aug 23, 2007·Chemistry & Biodiversity·Eric Stern, Didier M Lambert