Huanglongmycin A-C, Cytotoxic Polyketides Biosynthesized by a Putative Type II Polyketide Synthase From Streptomyces sp. CB09001

Frontiers in Chemistry
Lin JiangYong Huang

Abstract

Three natural products of nonaketide biosynthetic origin, probably biosynthesized from nine molecules of malonyl-CoA, have been isolated. Herein we described the isolation and structure elucidation of huanglongmycin (HLM) A-C and identification of the putative hlm biosynthetic gene cluster from Streptomyces sp. CB09001, isolated from a karstic cave in Xiangxi, China. Albeit previously isolated, HLM A was reported for the first time to exhibit moderate cytotoxicity against A549 lung cancer cell line (IC50 = 13.8 ± 1.5 μM) and weak antibacterial activity against gram-negative clinical isolates. A putative biosynthetic pathway for HLM A, featuring a nonaketide-specific type II polyketide synthase, was proposed. It would be consistent with the isolation of HLM B and C, which are two new natural products and likely shunt metabolites during HLM A biosynthesis.

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Citations

Sep 3, 2020·Natural Product Research·Lin JiangYong Huang
Apr 11, 2019·Frontiers in Microbiology·Pharada Rangseekaew, Wasu Pathom-Aree
May 29, 2019·Natural Product Research·Lin JiangYong Huang
Feb 5, 2021·Natural Product Research·Gui-Yun WuHai-Bo Tan
Jul 10, 2021·Frontiers in Microbiology·Tanim Arpit SinghElsayed Fathi Abd Allah
Oct 26, 2021·Microbial Ecology·Sahib ZadaRunlin Cai

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Datasets Mentioned

BETA
MG890330
CP026730

Methods Mentioned

BETA
NMR

Software Mentioned

antiSMASH

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