Huge variations in definition and reported incidence of postsurgical hypoparathyroidism: a systematic review

Endocrine
Torben HarsløfLars Rejnmark

Abstract

The reported incidence of post surgical hypoparathyroidism (HypoPT) varies greatly. Previous research suggests that the definition of HypoPT is not consistent in the literature. We therefore conducted a systematic review to investigate how HypoPT is defined and whether this definition, as well as the selected threshold for hypocalcemia affects the incidence. Using a predefined search string we identified all articles in PubMed reporting on the incidence of postsurgical HypoPT from 1st January 2010 to January 2017. We identified 89 articles that employed 20 different definition of HypoPT. The incidence of HypoPT varied from 0.0% to 20.2%. The definitions were not associated with incidence of HypoPT. Use of prophylactic post-operative calcium supplements, however decreased the risk of HypoPT (p = 0.03), and there was a trend towards a lower risk of HypoPT when using a definition of hypocalcemia below lower limit of the reference range (p = 0.09). The large number of definitions of HypoPT, as well as the huge variation in incidence point to a problem suggests that the awareness of HypoPT should be raised. Use of prophylactic post-operative calcium supplements may decrease risk of HypoPT. This, however, may be due to reverse causal...Continue Reading

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Citations

Apr 10, 2020·Scandinavian Journal of Surgery : SJS : Official Organ for the Finnish Surgical Society and the Scandinavian Surgical Society·David PalmhagInga-Lena Nilsson
Sep 13, 2020·The Journal of Clinical Endocrinology and Metabolism·Matthias BüttnerSusanne Singer
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Jun 15, 2021·Frontiers in Endocrinology·Liu XiaoLin Li
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Oct 8, 2021·JAMA Otolaryngology-- Head & Neck Surgery·Ivona LoncarTessa M van Ginhoven

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