PMID: 8948301Nov 1, 1996Paper

Hughes syndrome: a common problem in Kuwait hospitals

British Journal of Rheumatology
A N MalaviyaM A Hussain

Abstract

The objective was to study antiphospholipid antibody syndrome (APS or Hughes syndrome) in two major teaching hospitals in Kuwait. patients with suspected Hughes syndrome were investigated with tests for anticardiolipin antibodies (aCL) and lupus anticoagulants (LAC) over 1 yr. Diagnosis was considered confirmed if significant levels of either or both antibodies with no obvious cause (primary), or with systemic lupus erythematosus (SLE) or SLE-like illness (including SLE serology) (secondary) were present. Twelve (37.5%; seven females, 58%) primary and 20 (62.5%; 18 females, 90%) secondary Hughes syndrome patients were seen during this period. patients were Kuwaiti, Middle-Eastern and North-African Arabs (29). Filipinos (2) and White (1). None were from the Indian subcontinent. The main presentation was thrombosis in 75% (arterial in 25% and venous in 50%), and recurrent abortions in 50% of married women. Haematological and dermatological manifestations were limited entirely to the secondary variety, seen in 25% and 19%, respectively. Clinical manifestations were severe, leading to death in one, intensive-care management in 31% and with partial or complete warfarin resistance or brittleness in 25%. Neurological/eye and cardiac m...Continue Reading

Citations

Apr 12, 2007·Clinical Reviews in Allergy & Immunology·Graham Hughes
May 23, 2012·International Journal of Clinical Practice·G R V Hughes, Y Shoenfeld
May 28, 2005·Annals of the Rheumatic Diseases·I Uthman, M Khamashta
Jan 15, 2008·Autoimmunity Reviews·Graham R V Hughes
Jan 16, 1999·Baillière's Clinical Rheumatology·M C AmigoG R Hughes
Apr 18, 2000·Rheumatic Diseases Clinics of North America·M C Amigo, M A Khamashta
Jan 1, 1997·Lupus·A N MalaviyaP N Shamar
Jun 6, 2015·Lupus·G R V Hughes
Oct 31, 1998·Lupus·K Al-JarallahA N Malaviya
Nov 6, 2008·Psychological Reports·Omar Khaleefa, Richard Lynn

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Antiphospholipid Syndrome

Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by the presence of antibodies directed against phospholipids.