Hughes Syndrome (the antiphospholipid syndrome): ten clinical lessons

Autoimmunity Reviews
Graham R V Hughes

Abstract

The APS was described 25 years ago as a triad of manifestations (GRV Hughes). During the last 3 decades the disease became more systemic than systemic lupus erythematosus (SLE). The paper entails many of the old clinical findings as well as novel ones which are still not well documented in large series. The authors also refer to the second hit theory of infectious origin of APS. How to treat and indications for self monitoring the INR are detailed. The question of whether specific IVIG (directed against anti cardiolipin) or anti CD 20 be incorporated into the therapeutic armamentarium employed in APS will be answered in the near future.

References

Nov 1, 1996·British Journal of Rheumatology·A N MalaviyaM A Hussain
Jul 2, 2002·Lupus·S NairG R V Hughes
Sep 16, 2003·Annals of the Rheumatic Diseases·S R SangleG R V Hughes

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Citations

May 21, 2009·Clinical Rheumatology·P T Donnan, M J McDonald
Jun 27, 2009·Clinical Reviews in Allergy & Immunology·Aviva KatzavJoab Chapman
Oct 21, 2009·Clinical Reviews in Allergy & Immunology·Ricard Cervera, Juan Balasch
Mar 16, 2011·Clinical Reviews in Allergy & Immunology·Roberta GualtierottiPier Luigi Meroni
Jun 16, 2012·Human Reproduction Update·Christine A ClarkKaren A Spitzer
Apr 9, 2010·International Journal of Rheumatic Diseases·Graham R V Hughes
Dec 19, 2008·Arthritis Research & Therapy·Gerard Espinosa, Ricard Cervera
Sep 8, 2012·Autoimmune Diseases·Athina PyrpasopoulouSpyros Aslanidis
May 19, 2017·CEN Case Reports·David NavarroFernando Nolasco
Jan 23, 2010·Lupus·Graham R V Hughes
Feb 2, 2018·Modern Rheumatology·Olga Amengual, Tatsuya Atsumi
Jun 18, 2009·Current Opinion in Infectious Diseases·Richard StrattonSabine Kinloch-de Loes
Sep 18, 2009·Annals of the New York Academy of Sciences·Assaf MenachemAviva Katzav
Sep 18, 2009·Annals of the New York Academy of Sciences·Juliana M Pernambuco-ClimacoPaulo Louzada-Junior
Sep 18, 2009·Annals of the New York Academy of Sciences·Maria José SantosJosé Canas da Silva
Mar 3, 2010·European Journal of Clinical Investigation·Carlos E M RodriguesYehuda Shoenfeld
May 23, 2012·International Journal of Clinical Practice·G R V Hughes, Y Shoenfeld
Dec 1, 2008·Expert Review of Hematology·Maria Laura Bertolaccini, Munther A Khamashta
Jul 21, 2016·International Journal of Laboratory Hematology·D PérezA Serrano

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