Human β-defensin 1 update: Potential clinical applications of the restless warrior

The International Journal of Biochemistry & Cell Biology
Ángel H ÁlvarezErnesto Prado Montes de Oca

Abstract

Human β-defensin 1 (hBD-1) is a multifaceted antimicrobial peptide being a tumour suppressor and, depending on call of duty, capable of inducing self-nets and neutrophil extracellular traps (NETs) to capture and/or kill bacteria, participates in inflammatory responses in chronic diseases including hBD-3 upregulation and also capable of up/downregulation in the presence of certain species of Lactobacillus sp. Thus, is regulated by host microbiota. Alleles, genotypes and/or altered gene expression of its coding gene, DEFB1, have been associated with several human diseases/conditions ranging from metabolic/chronic (e.g. cancer), infectious (e.g. tuberculosis, HIV/AIDS), inflammatory (gastrointestinal diseases), male infertility and more recently, neurologic (e.g. depression and Alzheimer) and autoimmune diseases (e.g. vitiligo and systemic lupus erythematosus). The present update focuses on novel DEFB1/hBD-1 properties and biomarker features, its biological function and the pharmaceutical potential uses of antimicrobial peptide elicitors (APEs) or the engineered peptide in the treatment of hBD-1-related human diseases.

Citations

Jan 30, 2020·International Journal of Immunogenetics·Luis Antonio Cruz DíazErnesto Prado Montes de Oca
Apr 28, 2020·Current Topics in Medicinal Chemistry·Bruno CasciaroMaria Luisa Mangoni
Nov 17, 2020·Frontiers in Cellular and Infection Microbiology·Zixin QinZhi Liu
Jun 22, 2021·Frontiers in Cell and Developmental Biology·Sabina SanegreRosa Noguera
Dec 16, 2021·Photodermatology, Photoimmunology & Photomedicine·Hesham ZaherMaha Fathy Elmasry

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.