Human 17beta-hydroxysteroid dehydrogenase type 2 messenger ribonucleic acid expression and localization in term placenta and in endometrium during the menstrual cycle

The Journal of Clinical Endocrinology and Metabolism
M V MustonenP Vihko

Abstract

According to the current hypothesis, 17beta-hydroxysteroid dehydrogenases (17HSDs) regulate the extent of estrogen influence in the endometrium by converting estradiol (E2) locally into a biologically less active sex steroid, estrone (E1), and vice versa. Recently, we have shown that both 17HSD type 1 and type 2 are expressed in the human endometrium, and in the present work, using in situ hybridization, we show that 17HSD type 2 is localized in the glandular epithelial cells as previously shown for the type 1 enzyme, but in contrast to type 1, the expression of type 2 is highest at the end of the cycle. Hence, we hypothesize that the differential expression of the two 17HSD enzymes, with opposite activities in same cell types, could modulate intracellular E2 concentrations during the end of the luteal phase of the menstrual cycle. We further analyzed the expression of 17HSD type 1 and type 2 mRNAs in term human placenta. Expression of 17HSD type 1 mRNA was detected in the syncytiotrophoblasts, and signals for type 2 mRNA were found inside the villi, corresponding to cytotrophoblasts. The expression of 17HSD type 2 in the placenta may serve to maintain the presence of inactive sex steroids and attenuate the formation of biologi...Continue Reading

Citations

Nov 23, 2006·Reproductive Biology and Endocrinology : RB&E·Linda C Giudice
Nov 23, 2006·Reproductive Biology and Endocrinology : RB&E·Hilary O D CritchleyRobert M Brenner
Jun 3, 2005·Clinical Medicine & Research·Kai Qi ZhangJames K Burmester
Feb 13, 2001·Molecular and Cellular Endocrinology·P VihkoD Ghosh
Mar 18, 2004·Molecular and Cellular Endocrinology·P VihkoV Isomaa
Mar 26, 2003·The Journal of Steroid Biochemistry and Molecular Biology·P VihkoV Isomaa
Oct 22, 2003·The Journal of Steroid Biochemistry and Molecular Biology·Miguel Coca-PradosPirkko Vihko
Dec 16, 2003·The Journal of Steroid Biochemistry and Molecular Biology·Olayiwola O OduwolePirkko T Vihko
Apr 30, 2005·The Journal of Steroid Biochemistry and Molecular Biology·P VihkoS Törn
Jan 13, 2006·Molecular and Cellular Endocrinology·P VihkoA Pulkka
Jan 13, 2006·Molecular and Cellular Endocrinology·Serdar E BulunJ Julie Kim
Jan 31, 2017·Biochemical Pharmacology·Katharina R BeckAlex Odermatt
Sep 15, 2005·Endocrine Reviews·Henry N JabbourHilary O D Critchley
Mar 24, 2005·The Journal of Clinical Endocrinology and Metabolism·Tommi E VaskivuoJuha S Tapanainen
Oct 27, 2018·International Journal of Molecular Sciences·Douglas A GibsonPhilippa T K Saunders

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