Human acellular dermal wound matrix for treatment of DFU: literature review and analysis

Journal of Wound Care
A M Reyzelman, I Bazarov

Abstract

Diabetic foot ulcers (DFUs) affect a significant number of people and the treatment is challenging and costly. Since only a small portion of patients respond to standard care, the majority require more advanced wound healing interventions. Human acellular dermal matrices-regenerative tissue matrices derived from human tissue and processed from screened donated skin-can aid wound closure by restoring the missing physiological factors to the microenvironment. A literature review of the clinical literature was performed to estimate the comparative effectiveness of one specific human acellular dermal wound matrix (HADWM; Graftjacket regenerative tissue matrix) versus standard care in healing DFUs. Outcomes from three prospective, controlled clinical trials, which included 154 patients with DFUs, were pooled. A comparative analysis revealed a statistically significant reduction in mean wound healing time, 1.7 weeks, as well as a nearly four-fold improvement in the chance of healing ulcers treated with HADWM versus moist wound-care. These pooled results suggest that HADWM may improve healing outcomes for these difficult-to-heal lower extremity wounds. Alexander Reyzelman is a consultant for KCI, an Acelity company.

References

Jun 1, 1995·Burns : Journal of the International Society for Burn Injuries·D J Wainwright
Jun 2, 2001·Archives of Physical Medicine and Rehabilitation·E J PetersJ G Fleischli
Jul 12, 2002·Statistics in Medicine·Julian P T Higgins, Simon G Thompson
May 27, 2003·Diabetes Care·William A MarstonUNKNOWN Dermagraft Diabetic Foot Ulcer Study Group
May 26, 2004·Transplant Immunology·Stephen F Badylak
May 12, 2005·Journal of Vascular Surgery·Eliot N MostowUNKNOWN OASIS Venus Ulcer Study Group
Jun 9, 2005·Advances in Skin & Wound Care·Jeffrey A NiezgodaJason P Hodde
Nov 18, 2005·Lancet·David G ArmstrongUNKNOWN Diabetic Foot Study Consortium
May 26, 2006·International Wound Journal·Billy R MartinDavid G Armstrong
Jul 25, 2006·Annals of Plastic Surgery·Kevin KnoxFrancis Patterson
May 4, 2007·The Journal of Clinical Investigation·Harold Brem, Marjana Tomic-Canic
Nov 6, 2007·The Journal of Foot and Ankle Surgery : Official Publication of the American College of Foot and Ankle Surgeons·Daniel K Lee
Dec 25, 2007·The Journal of Foot and Ankle Surgery : Official Publication of the American College of Foot and Ankle Surgeons·Daniel K Lee
Mar 20, 2008·Foot & Ankle International·F Alan BarberRobert Bentley Anderson
Mar 21, 2009·Journal of the American Podiatric Medical Association·Brock A Liden, Melitta Simmons
Sep 26, 2009·Clinics in Podiatric Medicine and Surgery·Kevin G CornwellKenneth S James
Nov 26, 2009·The Journal of Craniofacial Surgery·Aron G NusbaumSeth R Thaller
Feb 6, 2010·Foot & Ankle International·Jay H RapleyAlan Barber
Sep 10, 2010·Journal of Vascular Surgery·Vickie R DriverGary Gibbons
Sep 18, 2010·Journal of the American Podiatric Medical Association·Stephanie C WuDavid G Armstrong
Nov 16, 2010·The Surgical Clinics of North America·Markéta Límová
Mar 1, 2011·The Journal of Foot and Ankle Surgery : Official Publication of the American College of Foot and Ankle Surgeons·J Palmer Branch
Apr 26, 2011·Trends in Molecular Medicine·Jeremy J Song, Harald C Ott
Mar 21, 2012·Current Diabetes Reviews·N PapanasE Maltezos
Apr 26, 2012·Annals of Plastic Surgery·James NeillWilliam Lineaweaver
Sep 1, 2010·The Journal of the American College of Certified Wound Specialists·Howard KimmelThomas W Gilbert

❮ Previous
Next ❯

Citations

Aug 23, 2016·International Wound Journal·Rhiannon L HarriesKeith G Harding
Jun 16, 2015·Journal of Wound Care·M L Williams, J E Holewinski
Nov 9, 2016·Plastic and Reconstructive Surgery. Global Open·Anouska DasguptaWilliam W Li
Jun 13, 2020·The International Journal of Lower Extremity Wounds·Fu-Hui JiangHong-Lin Chen
Jan 18, 2018·Critical Reviews in Food Science and Nutrition·Marcela de Sá Barreto da CunhaSandra Fernandes Arruda
Aug 28, 2018·Gefässchirurgie : Zeitschrift für vaskuläre und endovaskuläre Chirurgie : Organ der Deutschen und der Österreichischen Gesellschaft für Gefässchirurgie unter Mitarbeit der Schweizerischen Gesellschaft für Gefässchirurgie·B DorweilerH Diener
Jul 1, 2020·Advanced Healthcare Materials·Francesco SantarellaCathal J Kearney

❮ Previous
Next ❯

Methods Mentioned

BETA
amputation

Software Mentioned

Comprehensive Meta - Analysis
RevMan
Review Manager

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.