Human activated T lymphocytes modulate IDO expression in tumors through Th1/Th2 balance

The Journal of Immunology : Official Journal of the American Association of Immunologists
Jessica Godin-EthierRéjean Lapointe

Abstract

Previous cancer vaccination approaches have shown some efficiency in generating measurable immune responses, but they have rarely led to tumor regression. It is therefore possible that tumors emerge with the capacity to down-regulate immune counterparts, through the local production of immunosuppressive molecules, such as IDO. Although it is known that IDO exerts suppressive effects on T cell functions, the mechanisms of IDO regulation in tumor cells remain to be characterized. Here, we demonstrate that activated T cells can induce functional IDO expression in breast and kidney tumor cell lines, and that this is partly attributable to IFN-gamma. Moreover, we found that IL-13, a Th2 cytokine, has a negative modulatory effect on IDO expression. Furthermore, we report IDO expression in the majority of breast and kidney carcinoma samples, with infiltration of activated Th1-polarized T cells in human tumors. These findings demonstrate complex control of immune activity within tumors. Future immune therapeutic interventions should thus include strategies to counteract these negative mechanisms.

References

Dec 1, 1990·British Journal of Cancer·P WhitfordA M Campbell
Mar 22, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·P HwuH A Young
Apr 9, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andrew L MellorDavid H Munn
Sep 5, 2002·International Journal of Cancer. Journal International Du Cancer·Maria FribergScott J Antonia
Sep 17, 2002·Cell Death and Differentiation·F FallarinoP Puccetti
Oct 31, 2002·Nature Immunology·Erik B Finger, Jeffrey A Bluestone
Jan 17, 2003·The New England Journal of Medicine·Lin ZhangGeorge Coukos
Oct 28, 2003·Nature Immunology·Francesca FallarinoPaolo Puccetti
Jan 15, 2004·Trends in Molecular Medicine·David H Munn, Andrew L Mellor
Sep 2, 2004·Nature Medicine·Steven A RosenbergNicholas P Restifo
Nov 6, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Solomon O OdemuyiwaRedwan Moqbel
May 12, 2005·Cancer Immunology, Immunotherapy : CII·Jose Manuel CózarFrancisco Ruiz-Cabello Osuna
Aug 24, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Aikou OkamotoMitsuyoshi Urashima
Oct 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Steven A RosenbergSeth M Steinberg
Feb 21, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Gerald BrandacherAlbert Amberger
Nov 23, 2006·British Journal of Cancer·K InoF Kikkawa
Dec 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gaynor J BatesAlison H Banham
Dec 30, 2006·Cancer Immunology, Immunotherapy : CII·Marion WobserJuergen C Becker
Jan 31, 2007·Breast Cancer Research : BCR·Carine ChaveyGwendal Lazennec
Apr 4, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sameer A SiddiquiEugene D Kwon
Apr 18, 2007·The Journal of Experimental Medicine·Caroline AspordA Karolina Palucka
May 4, 2007·The Journal of Clinical Investigation·David H Munn, Andrew L Mellor
Jun 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Qiang GaoZhao-You Tang
Nov 1, 2007·Neoplasia : an International Journal for Oncology Research·Simon TurcotteRéjean Lapointe
Dec 8, 2007·Nature Reviews. Immunology·Andrew L Mellor, David H Munn
Jan 12, 2008·Cancer Immunology, Immunotherapy : CII·Duane H Hamilton, Peter A Bretscher
Apr 17, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kazuhiko InoFumitaka Kikkawa
Dec 5, 2008·Cancer Immunology, Immunotherapy : CII·Sandy PelletierRéjean Lapointe

❮ Previous
Next ❯

Citations

Aug 13, 2013·Cancer Immunology, Immunotherapy : CII·Sonia A PerezConstantin N Baxevanis
Jun 15, 2012·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Yan Wu, Limin Zheng
Feb 7, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Richard C WuLaszlo G Radvanyi
Aug 24, 2011·Circulation. Arrhythmia and Electrophysiology·Angeliki AsimakiJeffrey E Saffitz
Aug 16, 2011·The Journal of Clinical Investigation·Emilie MamessierDaniel Olive
Aug 10, 2017·FEBS Letters·Valérie Molinier-Frenkel, Flavia Castellano
Aug 29, 2018·British Journal of Pharmacology·Debashree BasudharDavid A Wink
Jul 21, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·B MikalsenG Haraldsen
Apr 3, 2013·Nature Reviews. Urology·Hiromi I Wettersten, Robert H Weiss
Nov 15, 2013·Expert Review of Vaccines·Constantin N BaxevanisSonia A Perez
Nov 15, 2012·Clinical Chemistry·Omran Abu Aboud, Robert H Weiss
Feb 9, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Justin KlineThomas F Gajewski
Feb 18, 2011·International Journal of Cancer. Journal International Du Cancer·Jocelyne JacquemierLuc Xerri
Jan 27, 2019·PloS One·Natsuko IgaKenji Kabashima
Dec 21, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Qiyi ZhaoLimin Zheng
Feb 11, 2021·Angewandte Chemie·Elisabeth HennesHerbert Waldmann
Jun 18, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·David PossamaïRéjean Lapointe
Mar 27, 2012·Nuclear Medicine and Biology·Csaba JuhászOtto Muzik

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Immunology : Official Journal of the American Association of Immunologists
Anastasia NijnikRobert E W Hancock
The Journal of Immunology : Official Journal of the American Association of Immunologists
S L ConstantR A Flavell
© 2022 Meta ULC. All rights reserved