PMID: 8132177Feb 1, 1994Paper

Human acute toxicity prediction of the first 50 MEIC chemicals by a battery of ecotoxicological tests and physicochemical properties

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
M C CallejaP Geladi

Abstract

Five acute bioassays consisting of three cyst-based tests (with Artemia salina, Streptocephalus proboscideus and Brachionus calyciflorus), the Daphnia magna test and the bacterial luminescence inhibition test (Photobacterium phosphoreum) are used to determine the acute toxicity of the 50 priority chemicals of the Multicentre Evaluation of In Vitro Cytotoxicity (MEIC) programme. These tests and five physiocochemical properties (n-octanol-water partition coefficient, molecular weight, melting point, boiling point and density) are evaluated either singly or in combination to predict human acute toxicity. Acute toxicity in human is expressed both as oral lethal doses (HLD) and as lethal concentrations (HLC) derived from clinical cases. A comparison has also been made between the individual tests and the conventional rodent tests, as well as between rodent tests and the batteries resulting from partial least squares (PLS), with regard to their predictive power for acute toxicity in humans. Results from univariate regression show that the predictive potential of bioassays (both ecotoxicological and rodent tests) is generally superior to that of individual physicochemical properties for HLD. For HLC prediction, however, no consistent ...Continue Reading

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Citations

Oct 1, 1994·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M C CallejaG Persoone
Aug 1, 1999·Toxicology in Vitro : an International Journal Published in Association with BIBRA·F PaillardJ A Vericat
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Jul 13, 2019·Biomimetics·Philippe TerrierEmmanuel Raufflet

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