Human acyl-CoA:cholesterol acyltransferase (ACAT) and its potential as a target for pharmaceutical intervention against atherosclerosis

Acta Biochimica Et Biophysica Sinica
Catherine C Y ChangTa Yuan Chang

Abstract

Acyl-CoA:cholesterol acyltransferase (ACAT) catalyzes the formation of cholesteryl esters from cholesterol and long-chain fatty-acyl-coenzyme A. At the single-cell level, ACAT serves as a regulator of intracellular cholesterol homeostasis. In addition, ACAT supplies cholesteryl esters for lipoprotein assembly in the liver and small intestine. Under pathological conditions, the accumulation of cholesteryl esters produced by ACAT in macrophages contributes to foam cell formation, a hallmark of the early stage of atherosclerosis. Several reviews addressing various aspects of ACAT and ACAT inhibitors are available. This review briefly outlines the current knowledge on the biochemical properties of human ACATs, and then focuses on discussing the merit of ACAT as a drug target for pharmaceutical interventions against atherosclerosis.

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Citations

Jun 30, 2012·American Journal of Physiology. Cell Physiology·Avery L McIntoshBarbara P Atshaves
Oct 30, 2016·Acta Biochimica Et Biophysica Sinica·Dongqing GuoBoliang Li
Jan 10, 2020·Environmental Science and Pollution Research International·Rania Abdelrahman ElgawishHeba M A Abdelrazek
Aug 5, 2009·Biological & Pharmaceutical Bulletin·Daisuke MatsudaHiroshi Tomoda
Sep 22, 2020·Pharmaceutical Biology·Zhiqin ZhangJian Ni
Jun 4, 2008·Biological & Pharmaceutical Bulletin·Daisuke MatsudaHiroshi Tomoda
Jan 15, 2009·American Journal of Physiology. Endocrinology and Metabolism·Ta-Yuan ChangYasuomi Urano
Jul 7, 2012·PloS One·Jin-Jian LuYi-Tao Wang
Feb 15, 2020·Current Pharmaceutical Design· AlamgeerArquimedes Gasparotto Junior
Jan 24, 2021·Molecular Metabolism·Imke L LemmerAlexander Bartelt
Nov 19, 2021·Frontiers in Pharmacology·Tingting ZhuGuifang Xu

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