Human adenovirus replication and persistence in hypertrophic adenoids and palatine tonsils in children

Journal of Medical Virology
José Luiz Proença-ModenaEurico Arruda

Abstract

The role of human adenovirus (HAdV) infection in different acute diseases, such as febrile exudative tonsillitis, conjunctivitis, and pharyngoconjunctival fever is well established. However, the relationships, if any, of HAdV persistence and reactivation in the development of the chronic adenotonsillar disease is not fully understood. The present paper reports a 3-year cross-sectional hospital-based study aimed at detecting and quantifying HAdV DNA and mRNA of the HAdV hexon gene in adenoid and palatine tonsil tissues and nasopharyngeal secretions (NPS) from patients with adenotonsillar hypertrophy or recurrent adenotonsillitis. HAdV C, B, and E were detectable in nearly 50% of the patients, with no association with the severity of airway obstruction, nor with the presence of recurrent tonsillitis, sleep apnea or otitis media with effusion (OME). Despite the higher rates of respiratory viral coinfections in patients with HAdV, the presence of other viruses, including DNA and RNA viruses, had no association with HAdV replication or shedding in secretions. Higher HAdV loads in adenoids showed a significant positive correlation with the presence of sleep apnea and the absence of OME. Although this study indicates that a significan...Continue Reading

References

Apr 1, 1977·American Journal of Epidemiology·J P FoxM K Cooney
Apr 1, 1973·Infection and Immunity·J van der Veen, M Lambriex
Jan 1, 1982·The Journal of Infectious Diseases·W A Andiman, G Miller
Jun 10, 1982·The New England Journal of Medicine·F W HendersonF W Denny
Jul 1, 1994·Infection and Immunity·A HåkanssonC Svanborg
Jul 1, 1994·American Journal of Respiratory and Critical Care Medicine·V MacekJ Marin
Mar 1, 1996·Journal of Medical Virology·P FlomenbergJ T Casper
Oct 9, 2002·Journal of Virology·C T GarnettLinda R Gooding
Dec 1, 1953·Proceedings of the Society for Experimental Biology and Medicine·W P ROWET G WARD
Jan 1, 1954·Proceedings of the Society for Experimental Biology and Medicine·M R HILLEMAN, J H WERNER
May 20, 2006·Reviews in Medical Virology·Manuel A F V Gonçalves, Antoine A F de Vries
Dec 26, 2008·Journal of Virology·C T GarnettL R Gooding
Nov 27, 2009·Journal of Clinical Microbiology·Ann TreacyWilliam W Hall
Aug 23, 2011·Seminars in Respiratory and Critical Care Medicine·Joseph P LynchMarcela Echavarria
Oct 31, 2013·Methods in Molecular Biology·Kazutaka Katoh, Daron M Standley
Feb 28, 2014·Pediatric Pulmonology·Keren Yeshuroon-KofflerAviv D Goldbart
Aug 8, 2014·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·M MutluE Miser
Nov 6, 2014·Molecular Biology and Evolution·Lam-Tung NguyenBui Quang Minh
Dec 4, 2014·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Arun Kumar Adhikary, Urmila Banik
Dec 30, 2015·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·K KosulinT Lion
Sep 22, 2016·American Journal of Physiology. Endocrinology and Metabolism·Jordan GainesEdward O Bixler
Oct 13, 2016·International Journal of Pediatric Otorhinolaryngology·Howard FadenKirsten St George
Oct 16, 2016·Medicine·Yu-Shu HuangLi-Ang Lee
Mar 18, 2017·PloS One·Ronaldo Bragança MartinsWilma Terezinha Anselmo-Lima
May 10, 2017·Nature Methods·Subha KalyaanamoorthyLars S Jermiin

❮ Previous
Next ❯

Citations

Dec 21, 2019·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Jacopo GalliGaetano Paludetti
Jun 9, 2020·Experimental Dermatology·Hanna NiehuesEllen H J van den Bogaard
Nov 27, 2019·FEBS Letters·Ashrafali Mohamed IsmailJames Chodosh
Dec 29, 2020·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Varvara ProbstNatasha B Halasa
Dec 28, 2019·International Journal of Pediatric Otorhinolaryngology·Robyn L MarshHeidi C Smith-Vaughan
Aug 19, 2021·Clinical and Experimental Otorhinolaryngology·Sung-Woo Cho, Seung Koo Yang

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsies
nucleic acid extraction
PCR
reverse
electrophoresis
bronchoalveolar

Software Mentioned

MAFFT
IQ
GraphPad Prism
FigTree
TREE

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.