Human adenovirus type 5 vectors expressing rabies glycoprotein

Vaccine
O K YaroshL Prevec

Abstract

The prevalence of wildlife rabies throughout the world and the continued spread of this disease in North America highlights the need for oral vaccines which may be used safely and effectively to vaccinate a number of species that are reservoirs or vectors of rabies. We have previously shown that AdRG1, a replication competent recombinant human adenovirus type 5 (Ad5) expressing a rabies glycoprotein (RG), can induce immunity to rabies in rodent, canine, and skunk model systems. To improve the Ad5 vector system as a potential oral vaccine, we have constructed additional Ad5 recombinant vectors and compared RG expression in cell culture and immunogenicity in animals. Two new replication competent vectors are compared. AdRG1.3, which carries RG with accompanying SV40 poly A addition sequences within an E3 deletion, and AdRG4, which has RG in the E3 deletion but under the control of an exogenous Ad2 major late promoter, both express higher levels of RG in permissive cell culture than did AdRG1 and both elicit high levels of serum anti-rabies antibodies by parenteral or oral routes in animals. AdRG1.3 may be a more effective vaccine vector in species which are non-permissive for the replication of human Ad5.

References

Jul 1, 1979·Journal of Biological Standardization·E ZalanD Pukitis
Jul 1, 1977·The Journal of General Virology·F L GrahamR Nairn
Jan 1, 1992·Archives of Virology·K M CharltonJ Armstrong
Jan 1, 1990·The Journal of Infectious Diseases·L PrevecF L Graham
Feb 1, 1989·The Journal of General Virology·M SchneiderL Prevec
Feb 1, 1989·The Journal of Cell Biology·M Kozak
Jan 1, 1989·Archives of Virology·C Kaplan
Nov 1, 1988·Reviews of Infectious Diseases·A I WandelerR Hauser
Nov 1, 1988·Reviews of Infectious Diseases·C E RupprechtH Koprowski
Apr 1, 1988·Journal of Wildlife Diseases·L D Barton, J B Campbell
Oct 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·C E RupprechtH Koprowski
Apr 1, 1973·Virology·F L Graham, A J van der Eb
May 21, 1973·JAMA : the Journal of the American Medical Association·T J WiktorD W Grella
Nov 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·T J WiktorM Mackett
Jul 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·K P Anderson, D F Klessig
Jan 1, 1982·Comparative Immunology, Microbiology and Infectious Diseases·F SteckL Schneider
Apr 1, 1983·The Journal of General Virology·M LafonR I Macfarlan

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Citations

Apr 13, 1999·Infectious Disease Clinics of North America·J D Gradon, L I Lutwick
Aug 1, 1997·Current Opinion in Immunology·M S Rolph, I A Ramshaw
Feb 8, 2003·DNA and Cell Biology·Chooi May LaiP Elizabeth Rakoczy
Dec 23, 2009·PLoS Neglected Tropical Diseases·Dennis SlateCharles E Rupprecht
Aug 7, 2012·Clinical and Experimental Immunology·D J HicksN Johnson
Aug 25, 2005·Expert Review of Vaccines·Louis H Nel
Nov 22, 2005·Vaccine·Dinesh S Bangari, Suresh K Mittal
May 18, 2005·Virus Research·Dennis SlateRichard B Chipman
Nov 21, 2009·Vaccine·Jacqueline WeyerLouis H Nel
Jul 9, 2013·Vaccine·Tricia L FryKurt Vercauteren
Jul 1, 2008·Advances in Virus Research·Susan A Nadin-Davis, Christine Fehlner-Gardiner
Nov 23, 2007·Critical Reviews in Microbiology·Louis H Nel, Wanda Markotter
Apr 20, 2017·International Journal of Molecular Sciences·Cyrielle Fougeroux, Peter J Holst
Dec 30, 2017·Human Gene Therapy·Qiong LinDe-Pei Liu
Apr 14, 2006·Veterinary Research·Volker GerdtsLorne A Babiuk
Oct 29, 2014·Expert Review of Vaccines·Manpreet KaurRakesh Bhatnagar
Jul 21, 2017·Tropical Medicine and Infectious Disease·Susan M MooreThomas Müller
Oct 20, 2000·The Journal of General Virology·W C Russell

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