Human adult and foetal liver sulphotransferases: inhibition by mefenamic acid and salicylic acid

Xenobiotica; the Fate of Foreign Compounds in Biological Systems
M VietriG M Pacific


1. The aim was to see whether mefenamic acid and salicylic acid had different inhibition profiles for SULT1A1 (substrate: 4-nitrophenol) and SULT1A3 (dopamine) activities and on (-)-salbutamol and minoxidil sulphation rates in the human adult and mid-gestational foetal livers. 2. The activity (pmolmin(-1) mg(-1) of SULT1A1 was 662 +/- 78 (adult) and 246 +/- 159 (foetus; p = 0.003) and that of SULT1A3 was 24 +/- 4 (adult) and 121 +/- 90 (foetus; p = 0.030). The rate (pmol min(-1) mg(-1)) of (-)-salbutamol sulphation was 109 +/- 27 (adult) and 117 +/- 34 (foetus; p = (0.144) and that of minoxidil sulphation was 202 +/- 38 (adult) and 108 +/- 44 (foetus; p = 0.001). 3. With mefenamic acid as an inhibitor, the IC50 (microM) for SULT1A1 was 0.2 +/- 0.004 (adult) and 0.01 +/- 0.002 (foetus; p = 0.001); for SULT1A3 it was 76 +/- 6 (adult) and 77 +/- 13 (foetus; p = 0.889); for the rate of ( )-salbutamol sulphation it was 0.07 +/- 0.005 (adult) and not determinable (foetus) and for minoxidil sulphation it was 1.6 +/- 0.7 (adult) and 0.15 +/- 0.04 (foetus; p = 0.076). 4. With salicylic acid as an inhibitor, the IC50 (microM) for SULT1A1 was 30 +/- 2 (adult) and 25 +/- 1 (foetus; p = 0.011); for SULT1A3 it was 690 +/- 36 (adult) and 570 ...Continue Reading


Sep 1, 1990·Biochemical Pharmacology·C N Falany, E A Kerl
Jan 1, 1988·European Journal of Clinical Pharmacology·P J Neuvonen, K T Kivistö
May 1, 1973·British Journal of Pharmacology·R T BrittainR J Marshall
Sep 1, 1971·Journal of Medicinal Chemistry·D Hartley, D Middlemiss
Dec 19, 1973·Biochimica Et Biophysica Acta·A Foldes, J L Meek
Dec 1, 1983·Journal of Medicinal Chemistry·J M McCallM G Wendling
Oct 7, 1995·BMJ : British Medical Journal·G M Turner, M G Coulthard
Mar 1, 1995·Clinical Pharmacokinetics·G M Pacifici, R Nottoli
Mar 1, 1997·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·G M PacificiR Gomeni
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