Abstract
Human aging is an inevitable and complex phenomenon characterized by a progressive, gradual degradation of physiological and cellular processes that leads from vulnerability to death. Mammalian somatic cells display limited proliferative properties in vitro that results in a process of permanent cell cycle arrest commonly known as senescence. Events leading to cellular senescence are complex but may be due to the increase in tumor suppressor genes, caused by lifetime somatic mutations. Cumulative mutation leaves an imprint on the genome of the cell, an important risk factor for the occurrence of cancer. Adults over the age of 65+ are vulnerable to age related diseases such as cancers but such changes may begin at middle age. MicroRNAs (miRNAs), which are small non-coding RNA, can regulate cancer progression, recurrence and metastasis. This chapter discusses the role of miRNA in tumor microenvironment, consequent to aging.
Citations
Oct 1, 2019·Current Pharmaceutical Design·Zhibo SunBo Zhang
Aug 30, 2019·Cancer Cell International·Kewei NiBing Zhou
Aug 2, 2020·Esophagus : Official Journal of the Japan Esophageal Society·Gui FuNasha Song
Jul 28, 2020·Frontiers in Genetics·Fei TangZhi-Yun Guo
Jun 11, 2020·World Journal of Clinical Cases·Li-Na YanZi-Ling Li
Jan 2, 2021·Frontiers in Cell and Developmental Biology·Heling YuYan Wang
Jan 21, 2021·Brain Sciences·Donata SimińskaIrena Baranowska-Bosiacka
Feb 4, 2021·Journal of Orthopaedic Surgery and Research·Beibei ZuJunxia Yang
Jan 9, 2021·Genomics & Informatics·Danbi SeoWanyeon Kim
Feb 16, 2021·Genomics·Weiyang LouWeimin Fan
Mar 7, 2021·Cancers·Iwona Nowak, Aishe A Sarshad
Mar 5, 2021·OncoTargets and Therapy·Hongzhu ZhangCuiping Zhang
Mar 16, 2021·The Journal of Clinical Investigation·Asurayya WorredeAshani T Weeraratna
May 1, 2021·Geriatrics·Antonino C TralongoMarco Danova
May 5, 2021·Cell Cycle·Minliang WuJianguo Xu
Jul 9, 2021·Oxidative Medicine and Cellular Longevity·Xuan LiuShuming Pan
Jul 16, 2021·Frontiers in Oncology·Weijie XueZhaojian Niu
Jul 1, 2021·Oncology Letters·Boyang LiuRuisheng Hao
Jul 31, 2021·PloS One·Yue JiangJun He
Aug 11, 2021·The International Journal of Biological Markers·Wenfeng LiuXin Yin
Sep 2, 2021·Molecular Medicine Reports·Fang LiPian Ying