Human Aging and Cancer: Role of miRNA in Tumor Microenvironment

Advances in Experimental Medicine and Biology
Oleta A SandifordPranela Rameshwar

Abstract

Human aging is an inevitable and complex phenomenon characterized by a progressive, gradual degradation of physiological and cellular processes that leads from vulnerability to death. Mammalian somatic cells display limited proliferative properties in vitro that results in a process of permanent cell cycle arrest commonly known as senescence. Events leading to cellular senescence are complex but may be due to the increase in tumor suppressor genes, caused by lifetime somatic mutations. Cumulative mutation leaves an imprint on the genome of the cell, an important risk factor for the occurrence of cancer. Adults over the age of 65+ are vulnerable to age related diseases such as cancers but such changes may begin at middle age. MicroRNAs (miRNAs), which are small non-coding RNA, can regulate cancer progression, recurrence and metastasis. This chapter discusses the role of miRNA in tumor microenvironment, consequent to aging.

Citations

Jun 11, 2020·World Journal of Clinical Cases·Li-Na YanZi-Ling Li
Jan 21, 2021·Brain Sciences·Donata SimińskaIrena Baranowska-Bosiacka
Jan 9, 2021·Genomics & Informatics·Danbi SeoWanyeon Kim
Mar 7, 2021·Cancers·Iwona Nowak, Aishe A Sarshad
Mar 16, 2021·The Journal of Clinical Investigation·Asurayya WorredeAshani T Weeraratna
May 1, 2021·Geriatrics·Antonino C TralongoMarco Danova
Jul 16, 2021·Frontiers in Oncology·Weijie XueZhaojian Niu
Aug 11, 2021·The International Journal of Biological Markers·Wenfeng LiuXin Yin

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