Human airway smooth muscle is structurally and mechanically similar to that of other species

The European Respiratory Journal
L Y M ChinC Y Seow

Abstract

Airway smooth muscle (ASM) plays a vital role in the exaggerated airway narrowing seen in asthma. However, whether asthmatic ASM is mechanically different from nonasthmatic ASM is unclear. Much of our current understanding about ASM mechanics comes from measurements made in other species. Limited data on human ASM mechanics prevents proper comparisons between healthy and asthmatic tissues, as well as human and animal tissues. In the current study, we sought to define the mechanical properties of healthy human ASM using tissue from intact lungs and compare these properties to measurements in other species. The mechanical properties measured included: maximal stress generation, force-length properties, the ability of the muscle to undergo length adaptation, the ability of the muscle to recover from an oscillatory strain, shortening velocity and maximal shortening. The ultrastructure of the cells was also examined. Healthy human ASM was found to be mechanically and ultrastructurally similar to that of other species. It is capable of undergoing length adaptation and responds to mechanical perturbation like ASM from other species. Force generation, shortening capacity and velocity were all similar to other mammalian ASM. These resul...Continue Reading

Citations

Nov 3, 2012·Journal of Allergy·Peter B NobleHoward W Mitchell
Jul 24, 2014·American Journal of Respiratory Cell and Molecular Biology·Harley T SyyongChun Y Seow
Aug 24, 2013·Journal of Applied Physiology·Audrey Lee-GosselinYnuk Bossé
Jan 9, 2020·American Journal of Physiology. Lung Cellular and Molecular Physiology·Morgan GazzolaYnuk Bossé
Feb 1, 2019·Journal of Engineering and Science in Medical Diagnostics and Therapy·Ynuk Bossé
Sep 11, 2020·Expert Review of Gastroenterology & Hepatology·Manori Vijaya KumariNiranga Manjuri Devanarayana
Sep 4, 2012·Journal of Applied Physiology
Apr 23, 2021·Journal of Applied Physiology·David C AdamsMelissa J Suter
May 4, 2021·Biological Trace Element Research·Farah AfrinLuqman A Khan

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