Human allogeneic AB0/Rh-identical umbilical cord blood cells in the treatment of juvenile patients with cerebral palsy

Cytotherapy
Yury A RomanovVladimir N Smirnov

Abstract

The term "cerebral palsy" (CP) encompasses many syndromes that emerge from brain damage at early stages of ontogenesis and manifest as the inability to retain a normal body position or perform controlled movements. Existing methods of CP treatment, including various rehabilitation strategies and surgical and pharmacological interventions, are mostly palliative, and there is no specific therapy focused on restoring injured brain function. During a post-registration clinical investigation, the safety and efficacy of intravenous infusion of allogeneic human leukocyte antigen (HLA)-unmatched umbilical cord blood (UCB) cells were studied in 80 pediatric patients with cerebral palsy and associated neurological complications. Patients received up to 6 intravenous infusions of AB0/Rh-identical, red blood cell-depleted UCB cells at an average dose of 250 × 10(6) viable cells per infusion. Patients were followed for 3-36 months, and multiple cell infusions did not cause any adverse effects. In contrast, in most patients who received four or more UCB cell infusions, positive dynamics related to significant improvements in neurological status and/or cognitive functions were observed. The results confirm that multiple intravenous infusions ...Continue Reading

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Citations

Feb 24, 2016·Bulletin of Experimental Biology and Medicine·A B SmulevichS M Radaev
Sep 25, 2017·Pediatric Research·Courtney A McDonaldSuzanne L Miller
Nov 6, 2017·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Hanhong ZhangKaiyun Chen
Dec 5, 2019·Journal of Neuroscience Research·Xirui PengXiaoyang Wang
Feb 14, 2017·Stem Cells Translational Medicine·Christopher R Nitkin, Tracey L Bonfield
Oct 13, 2020·Curēus·Varun VankeshwaramSafeera Khan
Feb 10, 2021·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Yanqun ChangWei Wei
Aug 13, 2021·Stem Cell Reviews and Reports·Catherine BrégèreRaphael Guzman

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