Human allograft rejection in humanized mice: a historical perspective.

Cellular & Molecular Immunology
M A Brehm, L D Shultz

Abstract

Basic research in transplantation immunology has relied primarily on rodent models. Experimentation with rodents has laid the foundation for our basic understanding of the biological events that precipitate rejection of non-self or allogeneic tissue transplants and supported the development of novel strategies to specifically suppress allogeneic immune responses. However, translation of these studies to the clinic has met with limited success, emphasizing the need for new models that focus on human immune responses to allogeneic tissues. Humanized mouse models are an exciting alternative that permits investigation of the rejection of human tissues mediated by human immune cells without putting patients at risk. However, the use of humanized mice is complicated by a diversity of protocols and approaches, including the large number of immunodeficient mouse strains available, the choice of tissue to transplant and the specific human immune cell populations that can be engrafted. Here, we present a historical perspective on the study of allograft rejection in humanized mice and discuss the use of these novel model systems in transplant biology.

References

Mar 6, 1992·Cell·P MombaertsV E Papaioannou
Mar 1, 1991·Plastic and Reconstructive Surgery·W P LeeA J Weiland
Oct 4, 1990·Nature·G M Fulop, R A Phillips
Feb 10, 1983·Nature·G C BosmaM J Bosma
Sep 13, 1994·Proceedings of the National Academy of Sciences of the United States of America·A G MurrayJ S Pober
Sep 17, 1996·Proceedings of the National Academy of Sciences of the United States of America·T BluntP A Jeggo
Dec 22, 1999·Clinical and Experimental Immunology·K G TournoyG G Leroux-Roels
Feb 29, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·L D ShultzD L Greiner
Jun 22, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·E J WagarD L Greiner
Nov 10, 2000·General Hospital Psychiatry·K Laederach-Hofmann, B Bunzel
Jan 6, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·E J SuchinL A Turka
May 5, 2001·Immunity·P Libby, J S Pober
Feb 28, 2002·World Journal of Surgery·Jon S Odorico, Hans W Sollinger
May 1, 2002·Transplantation·Clayton E MathewsEdward H Leiter
Jun 5, 2002·Annual Review of Biochemistry·Martin Gellert
Dec 5, 2002·Mutation Research·Alejandro D Bolzán, Martha S Bianchi
May 20, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Peter S Heeger
Apr 2, 2004·Nature Reviews. Immunology·Camillo Ricordi, Terry B Strom
May 14, 2004·The New England Journal of Medicine·David M Harlan, Kristina I Rother
Aug 17, 2004·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Scott J BanuelosMichael C Appel
Sep 17, 2004·The Journal of Clinical Investigation·Kian Peng KohJordan S Pober
Jan 5, 2005·PLoS Medicine·Mark A Naftanel, David M Harlan
Mar 12, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Ron ShapiroAlan B Leichtman
May 10, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Leonard D ShultzRupert Handgretinger
Jun 7, 2005·Nature Medicine·Robert I LechlerLaurence A Turka
Jun 29, 2005·Diabetes·Edmond A RyanA M James Shapiro
Oct 8, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Stephen L ShiaoJordan S Pober

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Citations

Apr 11, 2015·Clinical Science·Luciana BalboaRogelio Hernández-Pando
Jun 3, 2015·Inflammatory Bowel Diseases·Iurii KobozievMatthew B Grisham
Sep 1, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Emily H WaideChristopher K Tuggle
Nov 21, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·L L KenneyM A Brehm
Dec 14, 2016·Annual Review of Pathology·Nicole C WalshLeonard D Shultz
Aug 28, 2014·Current Opinion in Organ Transplantation·William M BaldwinRobert L Fairchild
Jan 12, 2019·Frontiers in Immunology·Rajeev K TyagiPriyanka Tyagi
Sep 16, 2020·Cancer Metastasis Reviews·Michael W LeeAnna Capasso
Nov 3, 2016·Cancer Research·J Jason MortonAntonio Jimeno

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