PMID: 6159369Aug 1, 1980Paper

Human alpha 1-microglobulin levels in various body fluids

Journal of Clinical Pathology
K TakagiT Kawai

Abstract

alpha 1-Microglobulin levels in serum and urine were estimated by using single radial immunodiffusion, resulting in the following mean values: umbilical cord blood serum, 40.6 mg/l; normal adult serum, 44.2 mg/l; and normal urine, 5.7 mg/24 h urine volume. Slightly higher levels of serum alpha 1-microglobulin were found in infants and the aged. Serum and urine alpha 1-microglobulin levels in patients with renal failure, however, were greatly increased, mean levels being 231.5 mg/l and 100.7 mg/24 h urine volume, respectively. Serum alpha 1-microglobulin levels in these patients correlated well with both serum creatinine and beta 2-microglobulin levels. Serum alpha 1-microglobulin level did not correlate positively with serum levels of other plasma proteins, such as alpha 1-antitrypsin, haptoglobin, complement, etc. Ouchterlony immunodiffusion also revealed the presence of alpha 1-microglobulin in synovial fluid, ascites, pleural effusion, amniotic fluid, cyst fluid, and cerebrospinal fluid. The levels of alpha 1-microglobulin in these fluids were measured by single radial immunodiffusion, except that its level in cerebrospinal fluid was measured by radioimmunoassay. Mean alpha 1-microglobulin concentration was 20.8 mg/l in syno...Continue Reading

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Citations

May 7, 1998·Journal of Biomedical Materials Research·M A WassallS P Denyer
Sep 1, 1991·Transplant International : Official Journal of the European Society for Organ Transplantation·F F DurajO Ringdén
Dec 8, 1980·Clinica Chimica Acta; International Journal of Clinical Chemistry·K TakagiT Kawai
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