Human alpha 2-macroglobulin as an inhibitor of insoluble trypsin.

Biochemical and Biophysical Research Communications
D HeumannT Vischer

Abstract

alpha 2-Macroglobulin binds to insoluble trypsin bound on agarose beads inducing a reduction of proteolytic activity of the enzyme towards large substrates such as azocasein. When trypsin was bound on other matrices like sheep red blood cells or latex beads, the inhibition of proteolytic activity by alpha 2-macroglobulin was complete. These results show that alpha 2-macroglobulin inhibits similarly both soluble and insoluble proteinases.

References

Aug 1, 1979·The Biochemical Journal·A J BarrettC A Sayers
Jun 26, 1975·Nature·J Ferluga, A C Allison
Dec 5, 1975·Biochimica Et Biophysica Acta·M T DebanneJ Dolovich
Mar 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·S PontremoliB L Horecker
Sep 1, 1973·The Journal of Clinical Investigation·P C Harpel, M W Mosesson
Oct 1, 1966·Clinica Chimica Acta; International Journal of Clinical Chemistry·P O Ganrot
Feb 15, 1983·Archives of Biochemistry and Biophysics·J B HowellM J Hunter
Jun 1, 1980·The Biochemical Journal·G S Salvesen, A J Barrett
Apr 30, 1981·Biochemical and Biophysical Research Communications·P Régnier
Nov 30, 1967·Biochemical and Biophysical Research Communications·T Chase, E Shaw

❮ Previous
Next ❯

Citations

Feb 15, 1992·European Journal of Biochemistry·O Guy-CrotteC Figarella
Jul 23, 2013·Clinica Chimica Acta; International Journal of Clinical Chemistry·Youji Shimazaki, Madoka Michhiro
Mar 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Elke CarioDaniel K Podolsky

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.