Human amelogenins: sequences of "TRAP" molecules

Calcified Tissue International
A G FinchamM L Snead

Abstract

The extracellular protein matrix of developing enamel includes a major class of proteins, the amelogenins, which are believed to be concerned in regulating enamel biomineralization. Previous studies have shown the amelogenins of the extracellular matrix to be a complex of proline-rich hydrophobic proteins which, it is suggested, arise through posttranslational and postsecretory processing of a primary ameloblast gene product. More recently, it has been shown that the human amelogenin gene is located on both the X and Y chromosomes raising the possibility that polymorphism at the level of the gene may also contribute to the observed complexity of these enamel matrix proteins. To investigate such possible amelogenin polymorphism in developing human dental enamel, individual fractionated by size-exclusion and reversed-phase high pressure liquid chromatography (HPLC). Two tyrosine-rich amelogenin polypeptides (TRAPs) of approximately 5 kDa in size were isolated from an individual human dentition and characterized by automated gas-phase sequencing. These polypeptides were found to be of 42 (TRAP-2) and 44 (TRAP-1) amino acid residues in length; TRAP-2 lacked a carboxy-terminal -Gly-Trp sequence as has previously been described for a...Continue Reading

References

Dec 1, 1987·Journal of Dental Research·T AobaE C Moreno
Jan 1, 1987·Archives of Oral Biology·P FargeL Dallaire
Dec 1, 1987·Advances in Dental Research·M F YoungJ D Termine
Dec 1, 1987·Advances in Dental Research·H ShimokawaM F Young
Dec 1, 1987·Advances in Dental Research·M L Snead, E C Lau
Jun 28, 1985·Biochemical and Biophysical Research Communications·M L SneadH C Slavkin
Dec 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·M L SneadH C Slavkin
Dec 7, 1984·Journal of Chromatography·B A BidlingmeyerT L Tarvin
Jan 1, 1983·Journal of Dental Research·A G FinchamJ D Termine
Jun 15, 1984·Biochemical and Biophysical Research Communications·T TakagiS Sasaki
Mar 1, 1982·Calcified Tissue International·A G FinchamJ D Termine
Apr 1, 1983·The Biochemical Journal·A G FinchamW C Cothran
Oct 1, 1981·Bioscience Reports·A G FinchamW C Cothran

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Citations

Jan 1, 1994·Calcified Tissue International·J Catalano-ShermanD Deutsch
Apr 1, 1991·Calcified Tissue International·A G FinchamM L Snead
Feb 27, 2001·Matrix Biology : Journal of the International Society for Matrix Biology·W LiP K DenBesten
Sep 22, 2009·Journal of Dental Research·T NaganoJ P Simmer
Jan 1, 1995·Connective Tissue Research·D DeutschA Palmon
Aug 11, 2007·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Alexandra MumuliduStephanie Lemoult
Mar 14, 2012·European Journal of Oral Sciences·Feroz KhanStefan Habelitz
Nov 1, 1996·Advances in Dental Research·D DeutschL Dafni
Jun 27, 2020·International Journal of Molecular Sciences·Ana Gil-Bona, Felicitas B Bidlack
Jan 27, 2017·Experimental and Therapeutic Medicine·Marzena Wyganowska-SwiatkowskaMalgorzata Kotwicka

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