Human amniotic fluid mathematical model: determination and effect of intramembranous sodium flux

American Journal of Obstetrics and Gynecology
M A CurranMichael G Ross

Abstract

A recently described mathematical model of human amniotic fluid dynamics used known and estimated rates of fetal fluid production (lung liquid and urine) and composition (osmolality) to enable calculation of previously unmeasured routes of amniotic fluid resorption, including fetal swallowing and intramembranous (across the amnion) water flow. This "osmolar" model assumed that only free water resorption occurred across the intramembranous route. We hypothesized that intramembranous flow also may include solutes and electrolytes because significant concentration gradients exist between amniotic fluid and fetal plasma. We used mass balance analysis to determine the direction and magnitude of intramembranous sodium flux and to assess the ability of a newly described "sodium" model to predict changes in amniotic fluid volume in response to changes in intramembranous electrolyte flow. Mathematical modeling was used to predict changes in amniotic fluid volume in response to changes in intramembranous electrolyte flow. Model predictions were calculated using published values for human amniotic fluid and fetal urine composition and volume. Ovine studies were used to derive lung fluid volumes and composition. Fetal swallowing and intram...Continue Reading

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Citations

Jan 18, 2011·Journal of Pediatric Surgery·Grace A NicksaTerry L Buchmiller
Feb 17, 2007·Placenta·M H BeallM G Ross
May 24, 2006·Pediatric Clinics of North America·Sergio Fefer, Pamela Ellsworth
Jan 18, 2014·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Ahmed M MagedWalaa A I Mostafa
Dec 19, 2003·European Journal of Clinical Nutrition·F Manz, A Wentz
Jul 20, 2018·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Robert A BraceDebra F Anderson
Jul 14, 2007·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·S M LeeH C Syn
Mar 12, 2008·Prenatal Diagnosis·Jeroen P H M van den WijngaardMartin J C van Gemert
Apr 11, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·A UmurM G Ross
Sep 5, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Robert A BraceCecilia Y Cheung
Jul 16, 2003·American Journal of Obstetrics and Gynecology·Rekha BajoriaRatna Chatterjee

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