Human amniotic membrane-derived epithelial stem cells display anticancer activity in BALB/c female nude mice bearing disseminated breast cancer xenografts

International Journal of Oncology
Nam-Hee KangKyung-Chul Choi

Abstract

Breast cancer is one of the most common malignant tumors and the leading cause of mortality among women. In this study, we propose a human stem cell transplantation strategy, an important method for treating various cancers, as a potential breast cancer therapy. To this end, we used human amniotic membrane-derived epithelial stem cells (hAECs) as a cell source for performing human stem cell transplantation. hAECs have multipotent differentiation abilities and possess high proliferative potential. We transplanted hAECs into female BALB/c nude mice bearing tumors originating from MDA-MB-231 breast cancer cells. Co-culturred hAECs and MDA-MB-231 cells at a ratio of 1:4 or 1:8 (tumor cells to stem cells) inhibited breast cancer cell growth by 67.29 and 67.33%, respectively. In the xenograft mouse model, tumor volumes were significantly decreased by 5-flurouracil (5-FU) treatment and two different ratios of hAECs (1:4 and 1:8) by 84.33, 73.88 and 56.89%, respectively. Treatment of nude mice with hAECs (1:4) produced remarkable antitumor effects without any side-effects (e.g., weight loss, death and bruising) compared to the mice that received only 5-FU treatment. Tumor progression was significantly reduced by hAEC treatment compared...Continue Reading

Citations

Mar 1, 2014·The Journal of Membrane Biology·Ana Catarina MamedeM F Botelho
Sep 24, 2013·Medical Hypotheses·Hassan NiknejadAbolhassan Ahmadiani
Dec 10, 2016·PloS One·Sabreen KhalilNoha Mousa
Oct 1, 2020·Journal of the American Podiatric Medical Association·Juan Carlos GoezFarzana Arif
May 22, 2019·Molecular Genetics & Genomic Medicine·Shiva Gholizadeh-Ghaleh AzizMaryam Pashaiasl
Oct 23, 2020·International Journal of Molecular Sciences·Chen QiuJinying Li

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