Human Amniotic Membrane for the Prevention of Intradural Spinal Cord Adhesions: Retrospective Review of its Novel Use in a Case Series of 14 Patients

Neurosurgery
Corey T WalkerPeter Nakaji

Abstract

Tethering after spinal surgery is caused by adhesions that arise from intradural tissue manipulation. Microsurgical detethering is the only treatment for symptomatic patients, but retethering occurs commonly and no treatment is widely available to prevent this complication. To apply human amniotic membrane (HAM) grafts, which are immune-privileged and known to possess antifibrogenic properties, in patients requiring microsurgical detethering. For this first-in-human use, we evaluated the safety and potential efficacy of these grafts for preventing retethering. We retrospectively reviewed the medical records of all patients who required detethering surgery and received an HAM graft between 2013 and 2016 at our institution after various previous intradural spinal surgeries. In all 14 cases, intradural lysis of adhesions was achieved, an HAM graft was sewn in place intradurally, and a dural patch was closed in a watertight fashion over the graft. Fourteen patients had received HAM grafts to prevent retethering. All patients had at least 6 mo of follow-up (mean follow-up, 14 mo). Retethering was noted in only 1 patient. Surgical re-exploration showed that the retethering occurred caudal to the edge of the HAM graft, with no tetheri...Continue Reading

References

Dec 1, 1979·The Journal of Infectious Diseases·H R Harrison, R T Riggin
Mar 1, 1991·Fertility and Sterility·R L YoungJ M Wheeler
Aug 1, 1987·The Laryngoscope·Y ZoharN Laurian
Aug 1, 1994·Journal of Neurosurgery·K A Smith, H L Rekate
Apr 16, 1996·Proceedings of the National Academy of Sciences of the United States of America·N BoudreauM J Bissell
May 20, 1998·Journal of Pediatric Orthopedics·M J ArchibeckP M Stevens
May 26, 1999·The British Journal of Ophthalmology·H S Dua, A Azuara-Blanco
Nov 30, 1999·Critical Reviews in Neurosurgery : CR·R BerjanoM Dujovny
Oct 16, 2001·Journal of Neurosurgery·S HüttmannK Roosen
Jan 9, 2004·Survey of Ophthalmology·Harminder S DuaV Senthil Maharajan
Jun 6, 2006·Neurosurgical Focus·B J IskandarW J Oakes
Sep 23, 2008·British Journal of Neurosurgery·R F SekulaP J Jannetta
May 1, 2009·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Huiren Tao, Hongbin Fan
Sep 23, 2009·Journal of Neurosurgery. Spine·Giannina L Garcés-AmbrossiGeorge I Jallo
Oct 5, 2010·Journal of Craniovertebral Junction and Spine·Adib A AblaVolker K H Sonntag
May 24, 2011·Journal of Neurosurgery. Spine·Jörg Klekamp
Sep 3, 2011·Journal of Korean Neurosurgical Society·Hyu Jin ChoiYoung-Min Kwon
Aug 1, 2012·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Hongsheng LiangXiangtong Zhang
Sep 10, 2013·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Massimo CaldarelliLuca Massimi
Oct 2, 2013·Journal of Neurological Surgery. Part B, Skull Base·Takahiro TomitaToshio Nikaido
Sep 17, 2014·Surgical Neurology International·Antonio López-GonzálezFrancisco Javier Márquez-Rivas
May 31, 2017·Clinical Spine Surgery : a Spine Publication·D Greg AndersonJulie O'Connell

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Citations

Apr 28, 2020·Journal of Korean Neurosurgical Society·Ji Yeoun LeeKyu-Chang Wang
Apr 4, 2020·Operative Neurosurgery·Daniel G EichbergTimur M Urakov
Jun 3, 2018·Acta neurochirurgica·Elisabetta MartonPierluigi Longatti
Apr 5, 2019·Case Reports in Surgery·Luca Guarda-NardiniDaniele Manfredini
May 31, 2021·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Elisabetta MartonGiuseppe Canova

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