Human and rat cutaneous mast cells: involvement of a G protein in the response to peptidergic stimuli

European Journal of Pharmacology
B Emadi-KhiavY Landry

Abstract

Recent evidence suggests that peptides induce the release of mediators from rat peritoneal mast cell by means of a receptor-independent mechanism, possibly involving an interaction with sialic acid residues at the cell surface followed by the activation of a guanine nucleotide binding protein (G protein). We have now examined the potential involvement of sialic acid residues and of G protein stimulation in the activation of both human and rat cutaneous mast cells by neuropeptide Y, its C-terminal fragments and the wasp venom peptide, mastoparan. Neuropeptide Y-(18-36) was the most effective histamine releaser of the fragments tested, the order of potency being neuropeptide Y-(18-36) > neuropeptide Y-(22-36) > neuropeptide Y-(1-36). This order of potency suggests that the effects of the peptides are not mediated through classical NPY receptors. The hydrolysis of sialic acid residues by neuraminidase and the inhibition of G proteins by benzalkonium chloride or pertussis toxin significantly inhibited the secretory response of cutaneous mast cells to neuropeptide Y-(18-36) and mastoparan. These results demonstrate that the peptidergic pathway described for the activation of peritoneal rat mast cells is also involved in the response...Continue Reading

References

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Citations

Mar 15, 1995·European Journal of Pharmacology·M MousliY Landry
Nov 26, 2003·European Journal of Pharmacology·Vassiliki GiannoulakiEkaterini Tiligada
Apr 20, 2000·European Journal of Pharmacology·K MoriK Furuhama
May 23, 1998·European Journal of Pharmacology·A ChahdiY Landry
Nov 10, 1998·The Journal of General Physiology·D LorenzM Bienert
May 5, 1998·Fundamental & Clinical Pharmacology·A ChahdiY Landry
Aug 30, 2008·Journal of Ethnopharmacology·Ben Chung Lap ChanHang Yung Alaster Lau
Oct 23, 2010·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J W RychterA B A Kroese
Jul 3, 2002·Biochemical Pharmacology·Laura RaimondiRenato Pirisino
Jun 29, 2004·Pulmonary Pharmacology & Therapeutics·David A GronebergAxel Fischer
Oct 6, 2009·Molecular Immunology·Hongchang QuJohn D Lambris
Sep 24, 2004·Journal of Molecular Recognition : JMR·Johannes OehlkeMichael Bienert
Jul 13, 2019·Journal of Leukocyte Biology·Hiroyuki OgasawaraMasato Noguchi
Aug 7, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hanneke P M van der KleijJohn Bienenstock

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