Human and veterinary antibiotics induce hormesis in plants: Scientific and regulatory issues and an environmental perspective

Environment International
Evgenios AgathokleousEdward J Calabrese

Abstract

Veterinary and human pharmaceuticals have been widely used in the developed world, thus increasing their accumulation in the environment and thereby posing ecological risks. Earlier studies report that active pharmaceutical ingredients induce hormesis in plants, i.e. at low doses may enhance plant health whereas at high doses may suppress plant vigor. There is hitherto no study critically reviewing the effects of antibiotics on plants within a hormetic context despite effects of low doses on plants can have implications to animals, including humans, and to ecological processes. This study critically reviews for first time antibiotic-induced hormesis in plants, both quantitatively and qualitatively. Hormesis was induced by several antibiotics in a variety of species and endpoints. The maximum stimulatory response (MAX) was commonly <1.5-fold the control response and the distance from MAX to no-observed-adverse-effect level (NOAEL) was commonly up to 10-fold. Further quantitative and qualitative evaluations are provided and discussed in relation to scientific and regulatory aspects. Low doses of antibiotics are equally important as high doses as they can negatively affect plants, depending on plant tissues and the time tissues ar...Continue Reading

Citations

Dec 19, 2020·Comprehensive Reviews in Food Science and Food Safety·Arturo Duarte-SierraJoseph Arul
Jan 9, 2021·The Science of the Total Environment·Preston AkengaSean Comber
Jun 18, 2020·Trends in Plant Science·Evgenios AgathokleousEdward J Calabrese
Dec 17, 2018·Chemico-biological Interactions·Evgenios AgathokleousEdward J Calabrese
Sep 15, 2019·Environment International·Jianzhi Huang, Huichun Zhang
Jul 23, 2019·Toxicology·Evgenios Agathokleous, Edward J Calabrese
May 28, 2019·The Science of the Total Environment·Costas J Saitanis, Evgenios Agathokleous
Jun 25, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Minashree Kumari, Arun Kumar
Jun 28, 2020·Ecotoxicology and Environmental Safety·Yilin LiuZhonghua Wu
Jun 17, 2019·Environmental Research·Evgenios AgathokleousEdward J Calabrese

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