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Human Antiviral Efficacy, Safety and Pharmacokinetics of RV521, an Inhibitor of the RSV-F Protein: A Randomized, Placebo-Controlled, Respiratory Syncytial Virus Challenge Study

Antimicrobial Agents and Chemotherapy

Nov 11, 2019

John P DeVincenzoEdward Littler

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Abstract

Effective treatments for respiratory syncytial virus (RSV) infection are lacking. We report a human proof-of-concept study for RV521, a small-molecule antiviral inhibitor of the RSV-F protein. In this randomized, double-blind, placebo-controlled trial (NCT03258502), healthy adults were ...read more

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Double-Blind Method
Drug Evaluation
Randomization
Respiratory syncytial virus
Virus
Nasal Lavage Fluid
Nasal Mucus
Inhibitors
Hemoglobin Memphis
Reverse Transcriptase Polymerase Chain Reaction
3
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Human Antiviral Efficacy, Safety and Pharmacokinetics of RV521, an Inhibitor of the RSV-F Protein: A Randomized, Placebo-Controlled, Respiratory Syncytial Virus Challenge Study

Antimicrobial Agents and Chemotherapy

Nov 11, 2019

John P DeVincenzoEdward Littler

PMID: 31712214

DOI: 10.1128/aac.01884-19

Abstract

Effective treatments for respiratory syncytial virus (RSV) infection are lacking. We report a human proof-of-concept study for RV521, a small-molecule antiviral inhibitor of the RSV-F protein. In this randomized, double-blind, placebo-controlled trial (NCT03258502), healthy adults were ...read more

Mentioned in this Paper

Double-Blind Method
Drug Evaluation
Randomization
Respiratory syncytial virus
Virus
3

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