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Human apolipoprotein A-II enrichment displaces paraoxonase from HDL and impairs its antioxidant properties: a new mechanism linking HDL protein composition and antiatherogenic potential

Circulation Research

Sep 25, 2004

Vicent RibasFrancisco Blanco-Vaca

Abstract

Apolipoprotein A-II (apoA-II), the second major high-density lipoprotein (HDL) apolipoprotein, has been linked to familial combined hyperlipidemia. Human apoA-II transgenic mice constitute an animal model for this proatherogenic disease. We studied the ability of human apoA-II transgeni...read more

Mentioned in this Paper

APOA2 gene
APOB gene
PON1 gene
Hydrolase
Hyperlipidemia, Familial Combined
Founder Mice, Transgenic
Protein Overexpression
Chimeric Proteins, Recombinant
LDL-1
Lipoproteins
Paper Details
References
  • References29
  • Citations52
123
  • References29
  • Citations52
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Human apolipoprotein A-II enrichment displaces paraoxonase from HDL and impairs its antioxidant properties: a new mechanism linking HDL protein composition and antiatherogenic potential

Circulation Research

Sep 25, 2004

Vicent RibasFrancisco Blanco-Vaca

PMID: 15388641

DOI: 10.1161/01.res.0000146031.94850.5f

Abstract

Apolipoprotein A-II (apoA-II), the second major high-density lipoprotein (HDL) apolipoprotein, has been linked to familial combined hyperlipidemia. Human apoA-II transgenic mice constitute an animal model for this proatherogenic disease. We studied the ability of human apoA-II transgeni...read more

Mentioned in this Paper

APOA2 gene
APOB gene
PON1 gene
Hydrolase
Hyperlipidemia, Familial Combined
Founder Mice, Transgenic
Protein Overexpression
Chimeric Proteins, Recombinant
LDL-1
Lipoproteins

Related Papers

Paper Details
References
  • References29
  • Citations52
123
  • References29
  • Citations52
12345...
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