PMID: 6403646Mar 1, 1983Paper

Human B cell variants immunoselected against a single Ia antigen subset have lost expression of several Ia antigen subsets

The Journal of Experimental Medicine
R S Accolla

Abstract

Two monoclonal antibodies, D1-12 and BT 2.2, recognizing two distinct subsets of human Ia molecules, NG1 and NG2, respectively, present in all individuals irrespective of their HLA-DR phenotype, have been used to immunoselect cell variants from the lymphoblastoid cell line Raji. Results showed that, irrespective of the monoclonal antibody used for immunoselection, the cell variants analyzed in this study had lost the expression of both D1-12-and BT 2.2-specific antigenic determinants. Moreover, the expression of antigenic determinants specific for a third family of Ia molecules, the DC-1 subset, were also lost in the cell variants. In contrast, expression of HLA A, B, and C common structures, as recognized by the W6.32 monoclonal antibody, as well as expression of surface immunoglobulins, were not affected. Possible mechanisms inducing such a coordinate loss of expression of several families of human Ia molecules are discussed.

References

Dec 1, 1978·The Journal of Experimental Medicine·R TosiD Pressman
Dec 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·D J Charron, H O McDevitt
Jan 1, 1975·European Journal of Immunology·M FerrariniM L Durante
May 1, 1981·Molecular Immunology·S CarrelR S Accolla
Dec 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·E O LongB Mach
Jul 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·P KavathasR DeMars
Jul 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·R S AccollaG Corte

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Citations

Nov 1, 1994·Medical Microbiology and Immunology·U F HartwigB Fleischer
Jan 1, 1995·International Journal of Clinical & Laboratory Research·S Sartoris, R S Accolla
Jan 1, 1990·Immunologic Research·B M PeterlinS Tsang
Jan 1, 1990·Immunologic Research·J B Rothbard, R Busch
Jan 1, 1990·Immunologic Research·C R Hume, J S Lee
Sep 25, 2009·Molecular and Cellular Biochemistry·Anastasiia AleksandrovaJoseph D Fontes
Jun 1, 1994·Molecular Immunology·N A MooneyD J Charron
Oct 1, 1995·Current Opinion in Genetics & Development·V Steimle, B Mach
Sep 28, 2001·Trends in Immunology·R S AccollaG Tosi
Jan 25, 2003·Tissue Antigens·M T CoirasM Sánchez-Pérez
Oct 4, 2005·Nature Reviews. Immunology·Walter ReithJean-Marc Waldburger
Oct 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J GuardiolaR S Accolla
Jul 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·K MiwaJ L Strominger
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·C R HumeJ S Lee
Sep 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M Sakurai, J L Strominger
Nov 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J H Sloan, J M Boss
Apr 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·F LatronR S Accolla
Jun 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·C DoyleJ L Strominger
May 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·B Bénichou, J L Strominger
Jun 1, 1988·The Journal of Experimental Medicine·W KochD Mathis
Jan 1, 1989·The Journal of Experimental Medicine·V LotteauJ L Strominger
Feb 11, 1993·Nucleic Acids Research·M N OmbraJ Guardiola

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