PMID: 15240676Jul 9, 2004Paper

Human B cells express functional TRAIL/Apo-2 ligand after CpG-containing oligodeoxynucleotide stimulation

The Journal of Immunology : Official Journal of the American Association of Immunologists
Troy J KempThomas S Griffith

Abstract

CpG-containing oligodeoxynucleotides (CpG ODN) have broad-ranging immunostimulatory effects, including the generation of antitumor immune responses. Analysis of different CpG ODN have identified two classes: CpG-A ODN, which stimulate high levels of IFN-alpha production from plasmacytoid dendritic cells and weakly activate B cells, and CpG-B ODN, which strongly activate B cells but stimulate low production of IFN-alpha from plasmacytoid dendritic cells. Previously, we observed that CpG-B ODN (2006) induces TRAIL/Apo-2 ligand (Apo-2L)-mediated killing of tumor cells by CD14(+) PBMC. In this study, we extend our investigation of CpG ODN-induced TRAIL/Apo-2L expression and activity in PBMC to include CpG-A ODN. Of the two classes, IFN-alpha production and TRAIL/Apo-2L-mediated killing of tumor cells was greatest with CpG-A ODN. Surprisingly, CD3(+), CD14(+), CD19(+), and CD56(+) PBMC expressed high levels of TRAIL/Apo-2L following CpG-A ODN stimulation. When isolated, the CD19(+) PBMC (B cells) were able to kill tumor cells in a TRAIL/Apo-2L-dependent manner. As with CD14(+) PBMC, CD19(+) sorted B cells were capable of up-regulating TRAIL/Apo-2L expression when stimulated with IFN-alpha alone. Interestingly, agonist anti-CD40 mAb ...Continue Reading

References

Nov 1, 1992·Japanese Journal of Cancer Research : Gann·E KuramotoT Tokunaga
May 1, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H M KantarjianM Talpaz
Dec 1, 1990·The Journal of Investigative Dermatology·I Gresser
Oct 1, 1987·Journal of Interferon Research·A Isaacs, J Lindenmann
Jan 1, 1986·Annual Review of Immunology·R B HerbermanJ R Ortaldo
Mar 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·P LindahlI Gresser
May 11, 1984·Nucleic Acids Research·J HiscottC Weissmann
Apr 6, 1995·Nature·A M KriegD M Klinman
Jan 1, 1994·Pharmacology & Therapeutics·B Wiemann, C O Starnes
Feb 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·A M KriegC A Stein
Mar 1, 1996·European Journal of Immunology·M HahneJ Tschopp
Oct 6, 1997·Proceedings of the National Academy of Sciences of the United States of America·G J WeinerA M Krieg
Mar 4, 1998·European Journal of Immunology·I JeremiasK M Debatin
Apr 29, 1998·European Journal of Immunology·S M Mariani, P H Krammer
May 29, 1998·European Journal of Immunology·S M Mariani, P H Krammer
Oct 1, 1998·European Journal of Immunology·M J Martínez-LorenzoA Anel
Jan 23, 1999·International Reviews of Immunology·E De Maeyer, J De Maeyer-Guignard
Apr 20, 1999·The Journal of Experimental Medicine·T S GriffithN A Fanger
Nov 24, 1999·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·A K EerolaP Pääkkö
Oct 12, 2000·Biochemical and Biophysical Research Communications·Q WangB M Evers
Apr 6, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·M BauerG B Lipford
Sep 14, 2001·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·K Takeda, S Akira
Feb 28, 2002·Annual Review of Immunology·Arthur M Krieg
Apr 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Veit HornungGunther Hartmann
Jun 11, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Britta V SternMagdalena Tary-Lehmann
Sep 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Klaus HeckelsmillerGunther Hartmann
Jan 14, 2003·Annual Review of Immunology·Kiyoshi TakedaShizuo Akira
Jan 31, 2003·European Journal of Immunology·Klaus HeckelsmillerGunther Hartmann
Apr 12, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sue E Blackwell, Arthur M Krieg
Apr 18, 2003·Clinical and Experimental Immunology·H ShibuyaS Hirohata
Apr 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Miren KerkmannGunther Hartmann
Jun 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Troy J KempThomas S Griffith
Oct 8, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anke S LonsdorfMagdalena Tary-Lehmann
Oct 14, 2003·Trends in Immunology·Daniela Verthelyi, Rainald A Zeuner
Nov 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Catharien M U HilkensIan M Kerr

❮ Previous
Next ❯

Citations

Mar 18, 2009·Omics : a Journal of Integrative Biology·Olha KhymenetsRafael de la Torre
Oct 29, 2011·Molecular Medicine·Matthew W Klinker, Steven K Lundy
May 12, 2011·International Reviews of Immunology·Cailin Moira WilkeWeiping Zou
Jan 1, 2011·Cancers·Lyse A NorianThomas S Griffith
Apr 4, 2014·Cancer Immunology, Immunotherapy : CII·Karīna SiliņaAija Linē
Apr 28, 2016·Journal of Translational Medicine·Jiusheng DengJacques Galipeau
Jun 20, 2017·Cellular & Molecular Immunology·Anushruti SarvariaAurore Saudemont
Apr 10, 2018·Cellular & Molecular Immunology·Si-Si WangLi Zhang
May 16, 2019·Cells·Anne LargeotJerome Paggetti
May 19, 2010·Expert Review of Clinical Immunology·Junichiro Mizuguchi
Jan 25, 2011·Expert Opinion on Investigational Drugs·Udo HoltickMartin R Weihrauch
Aug 16, 2012·Cancer Biology & Therapy·Joshua E Allen, Wafik S El-Deiry
Dec 28, 2016·Journal of Oral Science·Marco MascittiCorrado Rubini
Oct 6, 2017·BMC Immunology·Shireen NigarTakeshi Shimosato
Aug 12, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Qiao LiAlfred E Chang
Mar 16, 2018·Cancer Metastasis Reviews·Xun YuanGen Sheng Wu
Aug 14, 2019·JCI Insight·Soizic GaraudKaren Willard-Gallo
May 23, 2019·Frontiers in Immunology·Julian StaniekMarta Rizzi
Oct 16, 2019·Current Medical Science·Kai-Liang ZhaoWen-Juan Qin
Oct 3, 2019·Cancers·Duygu SagGerhard Wingender
Jun 26, 2020·Frontiers in Cell and Developmental Biology·Daria S ChulpanovaValeriya V Solovyeva
Mar 6, 2009·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Steven K Lundy
Oct 6, 2007·Immunologic Research·Mark P SimonsThomas S Griffith
Sep 8, 2011·Journal of Surgical Oncology·Jukes P NammAlfred E Chang
Sep 6, 2018·International Journal of Cancer. Journal International Du Cancer·Min LiuXiubao Ren
Oct 22, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Brad H Nelson
Mar 4, 2018·HNO·P J SchulerT K Hoffmann
Dec 2, 2020·International Journal of Molecular Sciences·Melanie KienzlRudolf Schicho
Nov 21, 2020·The FEBS Journal·Ludmila Cardoso AlvesPhilippe Krebs
May 17, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Barbara G MolenkampTanja D de Gruijl
Sep 24, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jie-Yi ShiJia Fan
Jun 22, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Qiao LiAlfred E Chang
Mar 29, 2019·Redox Biology·Sin Yee GunSiew Cheng Wong
Nov 3, 2020·Expert Review of Proteomics·Vladimir Jurisic
Nov 17, 2020·Frontiers in Immunology·Angel J RubioXuemei Zhong
Dec 29, 2020·Immunological Reviews·Daniel MichaudYuliya Pylayeva-Gupta
Oct 20, 2009·European Journal of Pharmacology·Peter A Holoch, Thomas S Griffith
Apr 13, 2021·Journal of Molecular Biology·Andre G Loxton, Ilana C van Rensburg
May 18, 2021·Frontiers in Immunology·Diego CatalánOctavio Aravena

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Cell Adhesion Molecules in the Brain

Cell adhesion molecules found on cell surface help cells bind with other cells or the extracellular matrix to maintain structure and function. Here is the latest research on their role in the brain.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.