Human basophil/mast cell releasability. VII. Heterogeneity of the effect of adenosine on mediator secretion.

Life Sciences
G MaroneS Quattrin

Abstract

5'-N-ethylcarboxamideadenosine (NECA) greater than 2-chloroadenosine greater than adenosine greater than N6-(R-phenyl-isopropyl)-adenosine (R-PIA) inhibited in vitro anti-IgE-induced histamine and peptide leukotriene C4 (LTC4) release from human basophils in a concentration-dependent fashion. Micromolar concentrations of adenosine, NECA and R-PIA potentiated the anti-IgE-stimulated release of histamine and LTC4 from human lung parenchymal mast cells. Submillimolar concentrations of adenosine, NECA and R-PIA inhibited in a concentration dependent manner the release of histamine and prostaglandin D2 (PGD2) from skin mast cells challenged with anti-IgE. These results demonstrate marked heterogeneity of the modulatory effect exerted by adenosine on mediator release from human basophils and mast cells.

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Citations

Jan 1, 1990·Molecular Aspects of Medicine·A Shock, G J Laurent
Oct 8, 2003·The Journal of Allergy and Clinical Immunology·Gianni MaroneMassimo Triggiani
May 30, 2001·Leukemia Research·G MaroneM Triggiani
Mar 1, 1991·Immunology Today·T R Mosmann, K W Moore
May 22, 1998·International Journal of Clinical & Laboratory Research·G MaroneM Triggiani
Dec 1, 1994·The Journal of Allergy and Clinical Immunology·G MaroneA Genovese
Jul 9, 2004·The Journal of Allergy and Clinical Immunology·S Mark DuffyPeter Bradding
Nov 1, 1990·Biochemical Pharmacology·G MaroneV Casolaro

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