Human Basophils Modulate Plasma Cell Differentiation and Maturation

The Journal of Immunology : Official Journal of the American Association of Immunologists
D Dijkstra, A Meyer-Bahlburg

Abstract

Basophils represent <1% of circulating leukocytes. They play a crucial role during allergy and helminth-induced Th2 responses. However, recent data also suggest a contribution to the pathogenesis of autoimmune diseases. Basophils from patients with systemic lupus erythematosus show an activated phenotype, correlating to disease activity. Furthermore, murine basophils or their mediators enhance memory responses and plasma cell (PC) survival, suggesting that they directly modulate the function of B cells. This is highly relevant with respect to human allergy and autoimmunity because a possible modulation of B cell differentiation by basophils could point to new therapeutic targets. Therefore, the interaction between human B cells and basophils and the mechanism underlying this interaction were investigated in detail. Using two different methods to induce PC differentiation, we found that human basophils enhance B cell proliferation, class switching, differentiation into PC, maturation of PC, and production of Igs, especially IgG. Basophil supernatants enhanced the expression of the B cell markers CD23 and CD40, which are important for B cell differentiation into IgG-producing PC. This was mainly IL-4 dependent. IL-3 amplified the...Continue Reading

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Citations

Dec 20, 2017·Human Vaccines & Immunotherapeutics·Salvatore ChirumboloAntonio Vella
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Apr 27, 2019·Frontiers in Immunology·Xiaoping ZhangQin Ning
Nov 19, 2020·Allergy·Kensuke MiyakeHajime Karasuyama

Related Concepts

Basophils
Cell Differentiation Process
Enzyme-Linked Immunosorbent Assay
Flow Cytometry
Lymphocyte Activation
Plasma Cells
Low affinity IgE receptor
CD40 Antigens
Reverse Transcriptase Polymerase Chain Reaction
Enzyme-Linked Immunospot Assay

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