Human benign prostatic hyperplasia: a stromal disease? New perspectives by quantitative morphology

Urology
H P Rohr, G Bartsch

Abstract

Stereology is of great value for better understanding the pathomorphogenesis of benign prostatic hyperplasia (BPH) and the hormonally controlled mechanism of abnormal overgrowth of the prostate gland, especially the stromal component. In human BPH a fourfold absolute increase of the stromal part and a nearly double increase of the glandular part is indicated. The relative and absolute increase of the stromal part is surprisingly constant in spite of variation of human BPH. Stromal overgrowth can be viewed as a central feature of BPH implicating altered mesenchymal-epithelial relationship. At the ultrastructural level in man and dog the volume density of the secretory droplets and lysosomes of the glandular cells is reduced. Stereology data confirm furthermore the activation of the smooth muscle cells suggesting an induction of stromal growth possibly induced by estrogen and/or androgen and an important role in glandular-stromal interactions.

Citations

Jun 1, 1984·Journal of Steroid Biochemistry·A Mariotti, M Mawhinney
Jun 1, 1985·Journal of Steroid Biochemistry·W D TilleyV R Marshall
Nov 1, 1986·Journal of Steroid Biochemistry·D HendersonM F el Etreby
Dec 1, 1984·Molecular and Cellular Endocrinology·M J Weinberger
Mar 30, 1999·Urology·L S MarksJ B deKernion
Feb 13, 2001·International Journal of Andrology·M I ArenasR Paniagua
Feb 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Paloma Alonso-MagdalenaJan-Ake Gustafsson
Jul 1, 1997·The Journal of Urology·S ClausH Schulze
Dec 18, 2013·Investigative Radiology·Miriam W LagemaatTom W J Scheenen
Apr 18, 2002·International Journal of Radiation Oncology, Biology, Physics·Joseph M KaminskiGerald E Hanks
Mar 29, 2014·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Miriam W LagemaatTom W J Scheenen
Jan 21, 1982·Journal of Theoretical Biology·M M Melicow
Feb 1, 1988·Urology·S S LeongG S Yu
Sep 21, 2005·The Journal of Surgical Research·John P Durham, Michael G Mawhinney
Sep 27, 2008·The Prostate·Lawrence D TrueThomas N Wight
Aug 13, 2005·Cell Biology International·Wellerson Rodrigo ScaranoSebastião Roberto Taboga
Jul 5, 2017·Nature Reviews. Urology·Mindy Kim Graham, Alan Meeker
Mar 1, 1993·Biulleten' eksperimental'noĭ biologii i meditsiny·B Ia RyzhavskiĭN B Murzina
Oct 1, 1992·Biulleten' eksperimental'noĭ biologii i meditsiny·B Ia Ryzhavskiĭ, E A Ivashkov
Jan 1, 1981·The Prostate·A Mariotti, M Mawhinney
Jul 31, 2013·Molecular Endocrinology·Kuo-Pao LaiChawnshang Chang

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