Human beta-defensin 1: a restless warrior against allergies, infections and cancer

The International Journal of Biochemistry & Cell Biology
Ernesto Prado-Montes de Oca

Abstract

Human beta-defensin 1 (hBD-1) is probably the most important antimicrobial peptide in epithelial tissues. Its alleles and/or altered gene expression have been associated with at least 20 human diseases. hBD-1 is a tumor suppressor and DEFB1 is the only innate immunity gene that shows long-term balanced selection and heterozygote advantage. It is unique in its constitutive expression, but is still capable of upregulation upon inflammatory or microbial stimuli. The present minireview focuses on hBD-1 properties, biological function, its proposed pathogenic mechanisms and the potential uses of elicitors, inhibitors or the peptide itself in the treatment of hBD-1-related human diseases including allergies, infections and cancer.

Citations

Jun 13, 2013·Human Immunology·Justyna JarczakEmilia Bagnicka
Jan 6, 2012·Journal of Tropical Medicine·Ernesto Prado Montes de Oca
Aug 4, 2011·BMC Infectious Diseases·Thomas TolfvenstamMartin L Hibberd
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Jan 3, 2013·International Journal of Dermatology·Ernesto Prado Montes de Oca, Wentian Li
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