Human beta-defensin-1: an antimicrobial peptide of urogenital tissues

The Journal of Clinical Investigation
E V ValoreT Ganz

Abstract

Antimicrobial peptides are widely distributed mediators of innate host defense in animals and plants. A 36 amino acid antimicrobial peptide belonging to the defensin family, and named human beta-defensin-1 (HBD-1), was purified recently from hemodialysate fluid, but its tissue sources were not identified. By Northern blotting, we found the highest concentrations of HBD-1 mRNA in the kidney and the female reproductive tract. In situ hybridization localized the HBD-1 mRNA in the epithelial layers of the loops of Henle, distal tubules, and the collecting ducts of the kidney and the epithelial layers of the vagina, ectocervix, endocervix, uterus, and fallopian tubes in the female reproductive tract. Using a novel technique designed to detect cationic peptides in urine, we recovered several forms of HBD-1 ranging in length from 36 to 47 amino acid (aa) residues and differing from each other by amino terminal truncation. The total concentration of HBD-1 forms in voided urine was estimated at 10-100 microg/liter, with individual variations in the total amount of HBD-1 peptides and the relative proportion of HBD-1 forms. Multiple forms of HBD-1 (size 36-47 aa) were also found in the blood plasma, bound to carrier macromolecules that re...Continue Reading

References

Jul 15, 1977·Science·R R ArnoldJ R McGhee
Aug 1, 1992·The Journal of Cell Biology·M E SelstedA J Ouellette
Mar 21, 1991·Journal of Immunological Methods·R I LehrerP Eisenhauer
Oct 1, 1991·The Journal of Clinical Investigation·R T Ellison, T J Giehl
May 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·G DiamondC L Bevins
Oct 1, 1985·The Journal of Clinical Investigation·T GanzR I Lehrer
May 1, 1984·Analytical Biochemistry·J Meinkoth, G Wahl
Jul 17, 1995·FEBS Letters·K W BenschW G Forssmann
May 1, 1995·Pharmacology & Therapeutics·T Ganz, R I Lehrer
Mar 1, 1993·The American Review of Respiratory Disease·C H LeeM A Kaliner
Dec 1, 1993·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J N Wilcox
May 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·G DiamondC L Bevins
Apr 1, 1996·The Journal of Clinical Investigation·E V ValoreT Ganz
May 14, 1996·Proceedings of the National Academy of Sciences of the United States of America·G DiamondC L Bevins
Jan 1, 1997·Current Opinion in Nephrology and Hypertension·E I Christensen, H Birn
Mar 1, 1997·American Journal of Respiratory Cell and Molecular Biology·P B McCray, L Bentley
Jun 26, 1997·Nature·J HarderJ M Schröder
Aug 5, 1997·Proceedings of the National Academy of Sciences of the United States of America·E D StolzenbergM Zasloff

❮ Previous
Next ❯

Citations

May 20, 1999·Biopolymers·D Andreu, L Rivas
Jun 15, 2007·Inflammatory Bowel Diseases·Jishu Shi
Sep 23, 1998·Clinical Immunology and Immunopathology·G Diamond, C L Bevins
Jun 13, 2003·Folia Microbiologica·P SímaK Sigler
Jan 15, 2004·American Journal of Respiratory Medicine : Drugs, Devices, and Other Interventions·Alexander M Cole, Alan J Waring
Apr 12, 2005·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Josef Johann SchneiderHans Christian Korting
Sep 7, 2007·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Milan Chromek, Annelie Brauner
Dec 28, 2012·Archives of Gynecology and Obstetrics·Shu-Qin ChenShu-Zhong Yao
Aug 24, 2010·Cell and Tissue Research·Linda Hazlett, Minhao Wu
Nov 23, 2010·Cell and Tissue Research·Tova DybvigHeather L Wilson
May 13, 2005·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Timo JahnukainenGianni Celsi
Jan 27, 2009·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M SchwaabS Dazert
Oct 3, 2003·Biochemical and Biophysical Research Communications·Rachel A Page, Afshan N Malik
Aug 28, 2004·Comptes rendus biologies·Tomas Ganz
Mar 12, 2005·Journal of the American Academy of Dermatology·Arash Izadpanah, Richard L Gallo
Jan 24, 2004·Microbes and Infection·Brian K WadeDaniel F Balkovetz
Mar 17, 2004·Peptides·Tung X NguyenRobert I Lehrer
Mar 17, 2004·Peptides·David L CoxWilliam M Shafer
May 17, 2003·Fertility and Sterility·Diana C FlemingRodney W Kelly
Aug 23, 2001·Journal of Immunological Methods·D L DiamondB A Dale
Jan 5, 2000·Journal of Immunological Methods·G H Gudmundsson, B Agerberth
Sep 13, 2003·Developmental and Comparative Immunology·David K MeyerholzMark R Ackermann
Oct 22, 2003·Molecular Immunology·Michael P Philpott
Oct 22, 2003·Molecular Immunology·John T GeorgeMona Bajaj-Elliott
Aug 2, 2003·Journal of Reproductive Immunology·Anne E KingRodney W Kelly
Jan 12, 2002·FEMS Microbiology Letters·Periathamby Antony Raj, Andrew R Dentino
Oct 20, 2001·Journal of Dermatological Science·S J SeoB I Ro
Nov 7, 2003·International Journal of Antimicrobial Agents·Kim A BrogdenBrian F Tack
Feb 27, 1999·Current Opinion in Immunology·R I Lehrer, T Ganz
Oct 14, 2004·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·V Cuneyt KalfaAlexander M Cole
Jul 15, 1999·The International Journal of Biochemistry & Cell Biology·J M Schröder, J Harder
Apr 29, 2005·The Journal of Molecular Diagnostics : JMD·Audrey N SchuetzAndrew N Young
Jul 15, 2000·Oral Microbiology and Immunology·W A BonassD A Devine
Dec 21, 2002·Immunological Reviews·ToddE ScheetzPaul B McCray
Sep 26, 2013·Mucosal Immunology·M A Ingersoll, M L Albert
Nov 3, 2005·Nature Clinical Practice. Gastroenterology & Hepatology·Jan WehkampEduard F Stange

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved